A Study of the Intervention Effect of a Hybrid Exercise Program on Elderly With Sarcopenia

Sarcopenia Clinical Trial

Official title:

White Box Modeling of Self-Determine Sequence Exercise Program Among Sarcopenic Elderly: Uncovers a Novel Strategy Overcoming Decline of Skeletal Muscle Area

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05694117
• Other study ID #: CCEE2019
• Status: Completed
• Phase: N/A
• Start date: March 20, 2019
• Est. completion date: January 10, 2020

Study information

• Verified date: February 2023
• Source: Northeast Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Sarcopenia is a geriatric condition characterized by a progressive decrease in skeletal muscle content and loss of muscle function. Resistance exercise, Taichi exercise and the hybrid exercise program consisting of the two aforementioned methods have been demonstrated could increase the skeletal muscle mass of the elderly with sarcopenia. However, note that the above contents may be performed in a different order in a treatment, equally important but less well understood is the sequence in which it should be performed. Surprisingly, the exercise sequence has not been comprehensively investigated. Therefore, investigators designed a self-ordered exercise program combining resistance exercise, tai chi and a hybrid exercise program to investigate whether the decline in skeletal muscle area could be better overcome and the reversal of sarcopenia in elderly with sarcopenia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 392
• Est. completion date: January 10, 2020
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 75 Years

Eligibility

Inclusion Criteria:

1. satisfied the Asian screening criteria for sarcopenia by the Asian Working Group for Sarcopenia;

2. age higher than 60 but less than 75 years of age.

Exclusion Criteria:

1. with serious illness or breathing failure;

2. with neuro-muscular diseases;

3. taking medication that has an effect on the function of skeletal muscles;

4. with conditions relating to the neurological system or the mental health;

5. in another scheduled training plan.

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Behavioral:
• self-determine sequence exercise program
The Taichi exercise utilized the simplified eight styles of Taichi. The resistance training program consisted of three cycles. In the first cycle, investigators used a light load but high repetitions (ranging from 40% to 60% of one repetition maximum and 12-20 repetitions). During the second phase of our training, investigators raised the training load by doing sets of moderate intensity and a medium number of repetitions (ranging from 60% to 80% of one repetition maximum and 5-12 repetitions). In the third cycle, investigators aimed to improve the participants' maximal muscular resistance by using a greater training load and fewer repetitions (ranging from 70% to 85% of one repetition maximum and 5-8 repetitions).
• resistance training
The resistance training program consisted of three cycles. In the first cycle, investigators used a light load but high repetitions (ranging from 40% to 60% of one repetition maximum and 12-20 repetitions). During the second phase of our training, investigators raised the training load by doing sets of moderate intensity and a medium number of repetitions (ranging from 60% to 80% of one repetition maximum and 5-12 repetitions). In the third cycle, investigators aimed to improve the participants' maximal muscular resistance by using a greater training load and fewer repetitions (ranging from 70% to 85% of one repetition maximum and 5-8 repetitions). Participants in the RTG completed four sets of each movement, with two to three minutes of rest between each set.
• Taichi exercise and resistance training
The training of the Taichi exercise and resistance training group consisted of two cycles, the first cycle was aimed at learning and consolidating Taichi exercise, and the second cycle was aimed at improving and consolidating. The Taichi exercise and resistance training group was scheduled for 30 min of Taichi exercise per training. The resistance training program consisted of three cycles. In the first cycle, investigators used a light load but high repetitions (ranging from 40% to 60% of one repetition maximum and 12-20 repetitions). During the second phase of our training, investigators raised the training load by doing sets of moderate intensity and a medium number of repetitions (ranging from 60% to 80% of one repetition maximum and 5-12 repetitions). In the third cycle, investigators aimed to improve the participants' maximal muscular resistance by using a greater training load and fewer repetitions (ranging from 70% to 85% of one repetition maximum and 5-8 repetitions).
• Randomly selected exercise program
Participants in the randomly selected exercise program group who chose Yijinjing exercise were required to complete one hour of Yijinjing exercise training, and those who chose Yijinjing exercise hybrid strength training had to complete half an hour of Yijinjing training. The resistance training program consisted of three cycles. In the first cycle, investigators used a light load but high repetitions (ranging from 40% to 60% of one repetition maximum and 12-20 repetitions). During the second phase of our training, investigators raised the training load by doing sets of moderate intensity and a medium number of repetitions (ranging from 60% to 80% of one repetition maximum and 5-12 repetitions). In the third cycle, investigators aimed to improve the participants' maximal muscular resistance by using a greater training load and fewer repetitions (ranging from 70% to 85% of one repetition maximum and 5-8 repetitions).

Locations

Country	Name	City	State
China	Chinese Center of Exercise Epidemiology	Changchun	Jilin

Sponsors (1)

Lead Sponsor	Collaborator
Northeast Normal University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Using quantitative CT to investigate the change of skeletal muscle area in sarcopenic elderly.	Participants will receive quantitative CT scans before and after the intervention to assess the change from baseline skeletal muscle area at 6 months.	Month 6
Primary	Using a Jamar hydraulic hand dynamometer to investigate change of handgrip in sarcopenic elderly.	Participants will receive a handgrip strength test before and after the intervention to assess the change from baseline handgrip strength at 6 months.	Month 6
Primary	Using a bioelectrical impedance body composition analyzer with a multifrequency device to investigate the change of relative skeletal muscle mass index in sarcopenic elderly.	Participants will receive a relative skeletal muscle mass index test before and after the intervention to assess the change from baseline relative skeletal muscle index at 6 months.	Month 6
Secondary	Collect participants' self-evaluation of their life state and physical state.	Participants were asked to write a self-assessment report of no more than 500 words before and after the intervention, including physical status and life status.	Month 6
Secondary	Collect video of participants throughout the intervention.	The entire intervention process was videotaped and video of the entire intervention process was collected from the participants.	Month 6