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Clinical Trial Summary

Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. Among potential therapeutic candidates, guanidinoacetate (GAA) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. Interestingly, GAA-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. Here, we plan to evaluate does creatine-GAA supplementation affects various biomarkers of sarcopenia in elderly.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04652921
Study type Interventional
Source University of Novi Sad, Faculty of Sport and Physical Education
Contact
Status Completed
Phase N/A
Start date September 15, 2020
Completion date December 31, 2021

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