Sarcopenia Clinical Trial
Official title:
Understanding Acute Sarcopenia: a Time-limited Cohort Study to Characterise Changes in Muscle Mass and Physical Function in Older Adults Following Hospitalisation
This study aims to characterise acute changes in muscle mass, strength, physical performance in hospitalised older adults. We will assess the impact of these changes upon physical function at three month follow-up, and assess for the impact of clinical and immune-endocrine factors upon these changes.
Study Design
Time-limited cohort study involving serial measurements of Bilateral Anterior Thigh Thickness
(BATT) using ultrasound, handgrip strength, physical performance, and physical function
measured using the Patient Reported Outcome Measures Information System (PROMIS®). We aim to
fully characterise changes in these patients, and will perform a comprehensive evaluation of
clinical factors including nutrition and physical activity, and measure immune-endocrine
markers of inflammation.
Study Participants
Elective colorectal surgery, emergency abdominal surgery, and medical patients aged 70 years
and older
Planned Size of recruitment target
56 elective colorectal patients, 56 emergency abdominal surgery patients, and 56 medical
patients with acute infections
Follow up duration
3 months
Primary research question
Does acute change in quadriceps muscle thickness, handgrip strength and/or physical
performance within one week of hospitalisation predict change in patient reported physical
function at three months?
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