Outcome of Exercise With a Towel in Elderly With Sarcopenia

Sarcopenia Clinical Trial

Official title:

Chang Gung Medical Hospital

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03258827
• Other study ID #: 201700238B0
• Status: Completed
• Phase: N/A
• Start date: September 1, 2017
• Est. completion date: June 30, 2018

Study information

• Verified date: July 2017
• Source: Chang Gung Memorial Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

As the proportion of older adults increases, elderly-related issues attract more attention. Sarcopenia is one of the popular elderly-related issues. Sarcopenia may induce decreased muscle strength, poor physical activity, even disability and increase rate of hospitalization and mortality. Therefore, we want to figure out the management for decreasing prevalence of sarcopenia in older adults. This trial is planned to perform during 2017/08/01~2017/12/31. We plan to enroll 60 elderlies who are sarcopenia. These patient will be divided into 2 group randomize. Experimental group will be received a set of exercise, composed by warm-up, strengthening training with a towel, cold-down, 60 minutes per time, 3 times per week. Control group will be suggested home-based walking activity. We will evaluate the patient's functional performance three times, before training, after training, post-training for three months, respectively. These results will be analyzed by repeated measure ANOVA.

Description:

As the proportion of older adults increases, elderly-related issues attract more attention. Sarcopenia is one of the popular elderly-related issues. Skeletal muscle is an important component for sustaining physical activity and storing protein. Protein of skeletal muscle is used as energy substrates in cases of starvation or under stress. As being aging, physical condition degenerates gradually. Older adults usually have multiple chronic diseases. Lesser physical function results in less physical activity. As a result, more muscle mass would be lost. In previous study, after the age of 50 year-old, muscle mass decreases 1-2% per year. The velocity of muscle mass decline increases after the age of 60 year-old. Sarcopenia may induce decreased muscle strength, poor physical activity, even disability and increase rate of hospitalization and mortality. Therefore, we want to figure out the management for decreasing prevalence of sarcopenia in older adults.

Exercise is an important method for preventing sarcopenia. In this study, we intend to design a set of exercise which is easily performed for older adults and also has preventing muscle mass loss effect. Towel is an important tool for exercise.

Duration to execute is during 2017/08/01~2017/12/31. We randomize these 60 older adults into 2 groups (experimental group and control group) and there are 30 older adults in each group. Those older adults are age above 65 year-old, have lower grip strength and slower walking speed. One assistant who doesn't know which group these older adults belonged to would record their basic information and is responsible for the evaluation. We will evaluate the older adults' functional performance three times, before training, after training, post-training for three months, respectively.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 53
• Est. completion date: June 30, 2018
• Est. primary completion date: April 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years to 85 Years

Eligibility

Inclusion Criteria:

1. age above 65 y/o

2. low muscle mass (male<7.0 kg/m2, female<5.4kg/m2, tested by Dual energy X-ray Absorptiometry)

3. with or without low grip strength (male< 26 kg, female <18 kg)

4. with or without low walk speed (= 0.8 m/s).

Exclusion Criteria:

1. cognitive impairment or can't follow order appropriately

2. elderlies with medical problems that they can't perform the exercise program

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Procedure:
• Exercise with a towel
Exercise program composes with warm-up, strengthening exercise, cold-down, 60 minutes/time, 3 times/week. A towel is an important tool for exercise. Total duration of the program is 3 months.
• Home-based exercise
Home-based program focuses on walking activity at fast speed, 3 times/week, 60 minutes/times. The total duration is 3 months.

Locations

Country	Name	City	State
Taiwan	Wujia Senior Citizens activity Center of Kaohsiung City Government	Kaohsiung

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fat mass	Dual-energy X-ray absorptiometry is used for measuring fat mass.	Baseline
Primary	Fat-free mass	Dual-energy X-ray absorptiometry is used for measuring fat-free mass.	Baseline
Primary	Bone mineral density	Dual-energy X-ray absorptiometry is used for measuring bone mineral density.	Baseline
Primary	Maximal grip strength	Handgrip dynamometer is used for measuring maximal grip strength.	Baseline
Primary	Walking speed	Participants are asked to walk at a comfortable speed to perform 10 meter walk test.	Baseline
Primary	Timed up and go test	At first, the participant sits down. Then the participant would be asked to stand up, walk straight for 3 meters, turn around, go back to the chair and sit down. The duration of whole test would be measured.	Baseline
Primary	Times of stand-up and sit-down within 30 seconds	The participant is asked to cross arm before the chest. The investigator would record the times of stand-up and sit-down within 30 seconds.	Baseline
Primary	6 minutes walking test	At first, the participant sits down for a rest for 10 minutes. The participant would be asked to walk as longer distance as the participant can within 6 minutes.	Baseline
Primary	Berg balance test	The investigator record scores of 14 items involved in Berg balance test for measuring balance of the old adults.	Baseline
Secondary	Fat mass	Dual-energy X-ray absorptiometry is used for measuring fat mass	Change between baseline and 3 month after training
Secondary	Fat mass	Dual-energy X-ray absorptiometry is used for measuring fat mass	Change between baseline and 6 month after training
Secondary	Fat-free mass	Dual-energy X-ray absorptiometry is used for measuring fat-free mass	Change between baseline and 3 month after training
Secondary	Fat-free mass	Dual-energy X-ray absorptiometry is used for measuring fat-free mass	Change between baseline and 6 month after training
Secondary	Bone mineral density	Dual-energy X-ray absorptiometry is used for measuring bone mineral density	Change between baseline and 3 month after training
Secondary	Bone mineral density	Dual-energy X-ray absorptiometry is used for measuring bone mineral density	Change between baseline and 6 month after training
Secondary	Maximal grip strength	Handgrip dynamometer is used for measuring maximal grip strength.	Change between baseline and 3 month after training
Secondary	Maximal grip strength	Handgrip dynamometer is used for measuring maximal grip strength.	Change between baseline and 6 month after training
Secondary	Walking speed	Participants are asked to walk at a comfortable speed to perform 10 meter walk test.	Change between baseline and 3 month after training
Secondary	Walking speed	Participants are asked to walk at a comfortable speed to perform 10 meter walk test.	Change between baseline and 6 month after training
Secondary	Timed up and go test	At first, the participant sits down. Then the participant would be asked to stand up, walk straight for 3 meters, turn around, go back to the chair and sit down. The duration of whole test would be measured.	Change between baseline and 3 month after training
Secondary	Timed up and go test	At first, the participant sits down. Then the participant would be asked to stand up, walk straight for 3 meters, turn around, go back to the chair and sit down. The duration of whole test would be measured.	Change between baseline and 6 month after training
Secondary	Times of stand-up and sit-down within 30 seconds	The participant is asked to cross arm before the chest. The investigator would record the times of stand-up and sitdown within 30 seconds.	Change between baseline and 3 month after training
Secondary	Times of stand-up and sit-down within 30 seconds	The participant is asked to cross arm before the chest. The investigator would record the times of stand-up and sitdown within 30 seconds.	Change between baseline and 6 month after training
Secondary	6 minutes walking test	At first, the participant sits down for a rest for 10 minutes. The participant would be asked to walk as longer distance as the participant can within 6 minutes.	Change between baseline and 3 month after training
Secondary	6 minutes walking test	At first, the participant sits down for a rest for 10 minutes. The participant would be asked to walk as longer distance as the participant can within 6 minutes.	Change between baseline and 6 month after training
Secondary	Berg balance test	The investigator record scores of 14 items involved in Berg balance test for measuring balance of the old adults.	Change between baseline and 3 month after training
Secondary	Berg balance test	The investigator record scores of 14 items involved in Berg balance test for measuring balance of the old adults.	Change between baseline and 6 month after training