Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT03080129 |
| Other study ID # |
SAR |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
April 11, 2017 |
| Est. completion date |
December 2026 |
Study information
| Verified date |
August 2023 |
| Source |
Medical University of Graz |
| Contact |
Vanessa Stadlbauer-Köllner, AssocProf Dr |
| Phone |
+4331638582282 |
| Email |
vanessa.stadlbauer[@]medunigraz.at |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis. Severity
of malnutrition correlates with progression of liver disease and leads to sarcopenia in
30-70% of cirrhotic patients. Malnutrition and sarcopenia are associated with an increased
risk of complications and mortality.
In cirrhosis the gut microbiome is altered leading to increased gut permeability, bacterial
translocation and inflammation. Since the microbiome is involved in nutrient uptake and
metabolism, it is hypothesized that microbiome alterations contribute to sarcopenia. A
prospective controlled cohort study to investigate the interrelation of microbiome changes
and sarcopenia in cirrhosis will be conducted. Furthermore the effect of nutritional
interventions on the microbiome in cirrhosis will be studied. From this study information on
how the gut microbiome composition and sarcopenia are associated in cirrhosis and if
modulation of the gut microbiome by nutritional interventions is feasible will be collected.
Description:
Scientific background
Protein-energy malnutrition (PEM) occurs in 65-90% of patients with chronic liver disease.
PEM is caused by various factors including poor dietary intake, loss of appetite, decreased
hepatic protein synthesis, malabsorption and hypermetabolism. It is associated with an
increased risk of complications including ascites, hepatic encephalopathy, variceal bleeding,
hepatorenal syndrome and mortality. There is a direct relation between the progression of the
liver disease and the severity of malnutrition.
Malnutrition and sarcopenia in liver cirrhosis patients
PEM leads to sarcopenia as a common, but frequently overlooked, complication. Sarcopenia is
defined as a decrease in muscle mass two standard deviations below the healthy young adult
mean. Sarcopenia is associated with aging, chronic diseases and malignancy. To determine the
severity of muscle wasting, computed tomography scan (CT) or magnetic resonance imaging (MRI)
are an objective and reproducible technique. Sarcopenia negatively impacts on survival,
correlates with the risk of infections, increases surgical risk and leads to a poor quality
of life. Besides PEM also inflammation is of importance in the development of sarcopenia.
Diversity in the microbiome in patients with liver cirrhosis and association with sarcopenia.
The gut microbiome of liver cirrhosis patients is altered compared to healthy individuals.
Dysbiosis leads to an increased gut permeability, bacterial translocation and inflammation.
This contributes to fibrogenesis and may also be related to hepatocarcinogenesis. Hence, new
treatment approaches in cirrhosis focus on changing the microbial landscape.
Modulation the gut microbiome may also be a strategy to reverse sarcopenia by reducing
systematic inflammation.
Hypothesis and aims
There is an association between gut microbiome composition, gut permeability and the
existence of sarcopenia in cirrhotic patients.
Primary hypothesis: Diversity of the gut microbiome is reduced in liver cirrhosis patients
with sarcopenia compared to those without sarcopenia or healthy controls.
Secondary hypotheses: There is an association between gut microbiome composition, biomarker
of gut permeability and bacterial translocation with the presence of sarcopenia in cirrhosis.
Oral nutrition supplements (ONS) can influence the composition of the gut microbiome, gut
permeability, bacterial translocation and inflammation. Sarcopenia can be diagnosed from
patients portraits.
Aims: to investigate:
- the composition of the gut microbiome
- biomarkers of gut permeability, bacterial translocation and inflammation
- the incidence and severity of sarcopenia
- the impact of oral nutrition supplements (ONS) on the gut microbiome
- whether artificial intelligence can be used to diagnose sarcopenia from face portraits.
