Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults

Sarcopenia Clinical Trial

Official title:

Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01489930
• Other study ID #: 07-007689
• Status: Completed
• Phase: N/A
• First received: November 18, 2011
• Last updated: December 9, 2011
• Start date: May 2008
• Est. completion date: February 2011

Study information

• Verified date: December 2011
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training.

Hypotheses.

1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program

2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age

3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program

4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age

Recruitment information / eligibility

• Status: Completed
• Enrollment: 67
• Est. completion date: February 2011
• Est. primary completion date: February 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy

• 18 to 30 or >65 years

• Males and Females

Exclusion Criteria:

• Regular Exercise Program

• Smoking

• Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)

• Drugs known to impair metabolic function (beta blockers, steroids)

• Allergies to lidocaine

• Physical disability that precludes exercise

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Behavioral:
• Endurance exercise
Participants will perform 8-weeks of endurance exercise training. Participants will train 5 days per week for 60 min at 65% of VO2 peak.
• Resistance exercise
Participants will perform 8-weeks of resistance exercise training. Participants will train 4 days per week for ~60 min. Two days will focus on lower body resistance training and two days will focus on upper body.
• Control/Combined training
Participants will perform 8-weeks of no exercise (control), followed by 8-weeks of combined endurance and resistance training. Participants will endurance train 5 days per week for 30 min at 65% of VO2 peak and resistance train 4 days per week for 30 min.

Locations

Country	Name	City	State
United States	Mayo Clinic	Rochester	Minnesota

Sponsors (1)

Lead Sponsor	Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Skeletal Muscle Protein Synthesis	The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.	Measured at week 0 (baseline) and week 8	No
Secondary	Mitochondrial Function	The investigators will determine the change from baseline in mitochondrial function. Measurments will be performed at baseline and following 8 weeks of exercise training.	Measured at week 0 (baseline) and week 8	No