Sarcopenia Clinical Trial
Official title:
Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This
are-related decline in skeletal muscle mass and skeletal muscle strength is a major
underlying factor contributing to many of the metabolic disorders and frailty of the
investigators rapidly expanding aging population. Endurance (aerobic) and resistance
exercise training programs have been shown to effectively reverse the age-related decline in
metabolic and contractile muscle functions. The investigators will measure synthesis rates
of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (> 65 yrs) people
to determine their response to 8 weeks each of endurance, resistance, combined endurance and
resistance training, or placebo exercise training.
Hypotheses.
1. to measure fractional synthesis rates of multiple muscle proteins and identify those
that are enhanced by an endurance exercise program
2. to determine whether changes in protein synthesis in response to endurance exercise
programs are dependent on age
3. to measure fractional muscle synthesis rates of multiple muscle proteins and to
identify those that are enhanced by a resistance exercise program
4. to determine whether changes in protein synthesis in response to resistance exercise
programs are dependent on age
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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