Evaluation of the Reproducibility of Jumping Mechanography

Sarcopenia Clinical Trial

— Jump  

Official title:

Evaluation of the Reproducibility of Jumping Mechanography in Older Adults and Comparison With Current Functional Assessment Tools

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01164670
• Other study ID #: H-2010-0011
• Status: Completed
• Phase: N/A
• First received: July 15, 2010
• Last updated: October 1, 2015
• Start date: May 2010
• Est. completion date: March 2011

Study information

• Verified date: March 2011
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Sarcopenia, the age-related decline in muscle mass and function (widely recognized as "frailty"), is increasingly being appreciated, primarily in the research environment. Interventions to prevent or treat sarcopenia can be anticipated to reduce falls, fractures and thereby to facilitate independence and improve quality of life for older adults. Unfortunately, there is no current consensus definition of sarcopenia, thereby impeding clinical recognition and treatment. It has been advocated that low appendicular (arm and leg) lean mass, as measured by DXA, be utilized as a clinical diagnostic tool to define sarcopenia. While such an approach is possible, however, muscle strength loss is more rapid than mass loss, indicating deterioration of muscle "quality." Muscle quality may be affected by changes at the neuromuscular, cellular or subcellular levels; parameters not detected by measuring mass alone. Clearly, tools evaluating muscle performance, not simply mass, are needed to optimally identify, and subsequently monitor, treatment of older adults with sarcopenia. While current tests of muscle power/function (e.g., chair-rising, self-selected gait velocity, etc.) do correlate with functional limitation in older adults, these existing tests have limitations in that they cannot be performed in all people, may have "yes/no" results rather than a continuous scale and may not be highly precise. Thus, improved muscle function assessment tools are needed, both clinically and in research venues. Jumping mechanography is very likely one such methodology.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 96
• Est. completion date: March 2011
• Est. primary completion date: March 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 70 Years and older

Eligibility

Inclusion Criteria:

• Ambulatory, community dwelling men and women age = 70 years

• Able and willing to sign informed consent

• Able to stand without assistance

Exclusion Criteria:

• Abnormalities on screening laboratory assessment deemed to be clinically significant by the study investigators

• History of myocardial infarction within the prior six months or ongoing angina

• History of injury or surgery within the prior six months which limits the ability to ambulate

• History of severe end-organ disease, e.g., cardiovascular, hepatic, hematologic, pulmonary, etc., which might limit the ability to complete this study

• History of malignancy with metastasis to the musculoskeletal system

• Neuromuscular disease impairing balance to the degree of not being able to stand without assistance

• BMD T-score of less than -3.5 at any measured site and a prior hip or vertebral fracture

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Sarcopenia

Locations

Country	Name	City	State
United States	University of Wisconsin Osteoporosis Clinical Center and Research Program	Madison	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
University of Wisconsin, Madison

Country where clinical trial is conducted

United States,