Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men

Sarcopenia Clinical Trial

— NDC  

Official title:

Responses of Muscle and Whole-body Protein Turnover to Ingestion of Differing Doses of Whey and Soy Protein With and Without Resistance Exercise in Elderly Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01062711
• Other study ID #: DMI 1484
• Status: Completed
• Phase: N/A
• First received: February 3, 2010
• Last updated: July 19, 2011
• Start date: July 2008
• Est. completion date: May 2011

Study information

• Verified date: July 2011
• Source: McMaster University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Interventional

Clinical Trial Summary

When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e. performing resistance exercise) and proper nutrition, in particular eating enough high quality protein, can help slow the loss of muscle mass or potentially even reverse it. Protein and resistance exercise are thought to do this by stimulating your muscle to make more proteins and/or potentially by slowing down the rate at which your body breaks proteins down. Whey protein is a high quality protein isolated from milk and is known to stimulate new protein synthesis for all proteins in your body. However, to date, the effect that whey protein has on muscle protein synthesis, particularly in the elderly has yet to be determined. Thus the purposes of this study are: 1) to determine if whey is an effective source of protein that will stimulate muscle protein synthesis in the elderly, similar to what we have previously seen in young persons; 2) to determine the smallest amount of whey protein to consume to maximally stimulate your muscle to make new proteins; 3) to see if performing resistance exercise will augment the increase in new muscle protein synthesis with whey consumption; and 4) to try and found out if whey is more effective than soy protein in stimulating new muscle protein synthesis and suppressing muscle protein breakdown in the elderly, similar to what we have previously seen in young persons

Recruitment information / eligibility

• Status: Completed
• Enrollment: 81
• Est. completion date: May 2011
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• Male

• Aged 60 to 80 years old

• Non-smoker

• Generally healthy and can tolerate the resistance exercise and protein drink

Exclusion Criteria:

• Allergies to whey, casein or soy

• Health problems such as: heart disease, rheumatoid arthritis of the knee joint, diabetes, poor lung function, uncontrolled hypertension, or any health conditions that might put participants at risks for this study

• Failed clearance for exercise participation by their medical doctor

• Failed an exercise stress test

• Taking metformin and/or other medications for the control of blood glucose even though one might not be classified as diabetic

• Taking prescribed blood thinners such as warfarin and heparin but excluding aspirin

• Taking medications for lung and kidney conditions but excluding medication for asthma that is under control

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Dietary Supplement:
• Whey or soy protein
Whey and casein are isolated milk proteins

Locations

Country	Name	City	State
Canada	McMaster University	Hamilton	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
McMaster University	National Dairy Council

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle protein synthesis		Acute within the day	No
Primary	whole body amino acid oxidation		acute within the day	No
Secondary	muscle protein breakdown		Acute within the day	No
Secondary	serum insulin		acute within the day	No
Secondary	plasma amino acid concentrations		acute within the day	No