Sarcoma Clinical Trial
Official title:
A Randomized, Open-Label, Phase 2 Trial of CMB305 (Sequentially Administered LV305 and G305) and Atezolizumab in Patients With Locally Advanced, Relapsed, or Metastatic Sarcoma Expressing NY-ESO-1
This is an open-label Phase 2 randomized study that will examine the use of the study agents,
CMB305 (sequentially administered LV305 which is a dendritic cell-targeting viral vector
expressing the New York Esophageal Squamous Cell Carcinoma 1 gene [NY-ESO-1] and G305 which
is a NY-ESO-1 recombinant protein plus glucopyranosyl lipid adjuvant-stable emulsion
[GLA-SE]) in combination with atezolizumab or atezolizumab alone, in participants with
locally advanced, relapsed or metastatic sarcoma (synovial or myxoid/round cell liposarcoma)
expressing the NY-ESO-1 protein.
There is no formal primary hypothesis for this study.
This study is designed to investigate and examine the time to progression and overall survival for CMB305 in combination with atezolizumab or atezolizumab alone in the treatment of participants with sarcoma expressing NY-ESO-1 protein. ;
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