Sarcoma Clinical Trial
Official title:
DNA Methylation-based Assays for Detecting Disease Spread in Rhabdomyosarcoma
RATIONALE: DNA analysis of tumor, blood, and bone marrow may help doctors predict if the
disease has been disseminated.
PURPOSE: This research trial studies DNA tests in detecting disseminated disease in tumor,
blood, and bone marrow samples from patients with rhabdomyosarcoma.
OBJECTIVES:
- To establish a panel of hypermethylation assays for minimal disseminated disease
analysis in rhabdomyosarcoma (RMS).
- To apply the hypermethylation assays to a series of bone marrow specimens from RMS
patients.
OUTLINE: Archived tumor, bone marrow, and peripheral blood samples are analyzed for DNA
hypermethylation by PCR-based assays and microarray assays. Results are then compared with
each patient's clinical and pathological characteristics, and outcomes. Patterns of locus
hypermethylation in tumor and paired bone marrow samples are also compared.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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