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NCT01365949 Clinical Trial

Biomarker in Tissue Samples From Patients With Ewing Sarcoma

Sarcoma Clinical Trial

Official title:
INI-1 Deletions in Ewing Sarcoma

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01365949
Other study ID # AEWS11B1
Secondary ID COG-AEWS11B1NCI-
Status Completed
Phase N/A
First received June 1, 2011
Last updated July 7, 2016
Start date May 2011

Study information
Verified date July 2016
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

Description:

OBJECTIVES:

- To determine the frequency of INI-1 protein loss in Ewing Sarcoma.

OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date
Est. primary completion date July 2016
Accepts healthy volunteers No
Gender Both
Age group N/A to 120 Years
Eligibility DISEASE CHARACTERISTICS:

- Diagnosis of Ewing sarcoma

- Prepared tissue microarray with Ewing sarcoma samples available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Genetic:
• microarray analysis

• protein analysis

Other:
• immunohistochemistry staining method

• laboratory biomarker analysis

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome
Type Measure Description Time frame Safety issue
Primary Frequency of INI1 protein loss in Ewing Sarcoma No
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