Sarcoma Clinical Trial
Official title:
Glucose Metabolic Response by PET/CT to Sarcoma Treatments
RATIONALE: Diagnostic procedures, such as PET scan and CT scan, may help doctors determine
the extent of cancer and predict a patient's response to treatment and help plan the best
treatment.
PURPOSE: This clinical trial is studying how well PET scan combined with CT scan evaluates
treatment response in patients undergoing treatment for bone cancer or soft tissue sarcoma.
OBJECTIVES:
- Determine whether an FDA-approved device that combines fludeoxyglucose ^18F
positron-emission tomography (FDG-PET) and CT scanning (FDG-PET/CT) can accurately
locate and determine the extent of disease in patients who are undergoing treatment for
bone or soft tissue sarcoma.
- Determine whether FDG-PET/CT scanning is effective in evaluating the response of sarcoma
to treatment.
- Determine whether the new FDG-PET/CT device improves the ability to evaluate treatment
response early and accurately.
- Correlate changes in glucose metabolic activity early and late after treatment with
overall and progression-free survival.
- Correlate changes in glucose metabolic activity early and late after treatment with
degree of tumor necrosis at the time of surgery.
OUTLINE: This is a prospective, pilot study. Patients are stratified according to disease
(high-grade soft tissue sarcoma vs low-grade soft tissue sarcoma vs osteosarcoma).
Patients undergo fludeoxyglucose ^18F positron-emission tomography (FDG-PET)/CT scanning at
baseline and then within 2 weeks and 12 weeks after the start of treatment (total of 3
scans).
PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.
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