Sarcoma Clinical Trial
Official title:
Evaluation of Topotecan in the Treatment of Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of topotecan in treating patients with
recurrent or refractory cancer of the uterus.
OBJECTIVES: I. Estimate the antitumor activity of topotecan in patients with recurrent or
refractory carcinosarcoma of the uterus who have failed standard therapy. II. Determine the
nature and degree of toxic effects of topotecan in these patients.
OUTLINE: Patients receive topotecan IV over 30 minutes daily for 5 days. Treatment repeats
every 3 weeks for a minimum of 1 course in the absence of disease progression or
unacceptable toxicity. Patients with complete response, partial response, or stable disease
continue treatment for at least three courses. Patients are followed every 4 months for 2
years, every 6 months for 3 years, and then periodically thereafter until death.
PROJECTED ACCRUAL: Approximately 25-40 patients will be accrued for this study within 2
years.
;
Primary Purpose: Treatment
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