Sarcoidosis Clinical Trial
Official title:
Endobronchial vs. Esophageal Ultrasound for Diagnosing Sarcoidosis: A Randomized Clinical Trial; - A Standard vs. - ProCore Needle Comparison -
Rationale:
Endosonography with mediastinal/ hilar nodal sampling is the test of choice to diagnose
sarcoidosis stage I and II - in case tissue verification of noncaseating granulomas is
indicated. However, the optimal endosonographic approach (endobronchial or transoesophageal)
for mediastinal nodal sampling is under discussion.
Secondly, which needle size or type provides optimal tissue sample quality for granuloma
detection is unknown. The novel 25 Gauge (G) beveled ProCore needle, allows tissue
acquisition of small core biopsies in addition to cytological aspirates.
Hypotheses:
1. Esophageal ultrasound guided (EUS-B) sampling of intrathoracic lymph nodes has a 14%
higher granuloma detection rate compared to endobronchial ultrasound (EBUS) guided
nodal sampling in patients with suspected sarcoidosis stage I/II.
2. 25G ProCore needles provide superior sample quality compared to conventional 22G
needles in patients with suspected sarcoidosis stage I/II.
Study design:
Investigator initiated, randomized clinical trial. Setting: International, multicenter
(university and general hospitals)
Study population:
Consecutive patients with a clinical and radiologic suspicion of sarcoidosis stage I or II
and an indication for tissue verification of non-caseating granulomas are eligible for
inclusion.
Intervention:
EBUS vs EUS-B, simultaneously comparing the standard vs novel ProCore needles.
Main study endpoints:
1. The granuloma detection rate of endobronchial (EBUS) guided sampling of intrathoracic
lymph nodes compared to esophageal (EUS-B using the EBUS scope) guided sampling in
patients with suspected sarcoidosis stage I/II.
2. Sample quality of conventional 22G vs. 25G ProCore needles in patients with suspected
sarcoidosis stage I/II.
n/a
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Diagnostic
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