Sarcoidosis Clinical Trial
Official title:
EXercise TRAining in Sarcoidosis (EXTRAS Study): A Prospective, Randomized, Controlled, Crossover Trial
Exercise intolerance and reduced health status have been found in patients with sarcoidosis
and has been related to skeletal muscle weakness. The present researchers reason that
skeletal muscle weakness is, at least in part, related to physical inactivity and therefore
partially reversible following a structured exercise training program. Nevertheless, the
effects of exercise training have never been studied in patients with sarcoidosis.
Therefore, the present study is undertaken to explore the effects of exercise training in
patients with sarcoidosis. A priori, the following hypotheses are formulated:
- A 12-week exercise training program improves health status, quality of life and
exercise capacity in patients with sarcoidosis as compared to sarcoidosis patients
without exercise intervention.
- A 12-week exercise training program improves skeletal muscle function and reduces
complaints of anxiety and depression in patients with sarcoidosis as compared to
sarcoidosis patients without exercise intervention.
- A 12-week exercise training program reduces circulating levels of inflammatory markers
in patients with sarcoidosis as compared to sarcoidosis patients without exercise
intervention.
The EXTRAS study is a prospective, randomized, controlled, 24-week crossover clinical trial in which the participants are randomly assigned to receive 12 weeks of dynamic resistance and whole-body endurance exercises followed by 12 weeks without intervention or vice versa. Consenting participants will be assessed at baseline (before randomization, week 0) and at weeks 12 and 24. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind
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