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Dietary Salt and Microvascular Function

Salt; Excess Clinical Trial

Official title:
Influence of High Salt Diet on Microvascular Reactivity in Young Healthy Subjects

Clinical Trial Summary

It is well accepted that high-salt (HS) intake is an essential risk factor in development and progression of hypertension. Results of some recent studies suggest that some of the deleterious effects of a HS diet are independent of elevated blood pressure (BP) and may occur in normotensive individuals and are associated with impaired endothelial function. However, the effects of acute salt loading on endothelial function and vascular reactivity in young healthy individuals are still scarce and inconsistent.

The purpose of present study is to determine whether one week of HS intake affects microvascular reactivity in young healthy subjects without changes in BP. In addition, the investigators sought to evaluate if potential HS diet-induced microvascular dysfunction is associated with changes in oxidative stress level and/or with modification of immunological response in young healthy subjects.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02727426
Study type Interventional
Source Josip Juraj Strossmayer University of Osijek
Contact Ana - Stupin, MD, PhD
Phone +385915134958
Email anacavka@mefos.hr
Status Recruiting
Phase N/A
Start date February 2016
Completion date December 2017
View Details
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