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Clinical Trial Summary

The goal of this single-center, prospective clinical trial is to test the safety and efficacy of belimumab combined with multi-target therapy in the treatment of severe lupus nephritis. The main questions it aims to answer are: lupus nephritis complete remission rate at week 24, and the partial remission rate and safety assessments. Patients with severe lupus nephritis will be enrolled and received pulse methylprednisolone at a dose of 1.5 to 3.0g, followed by intravenous belimumab at a dose of 10mg per kilogram at weeks 2, 4, and 6, and every 4 weeks thereafter. Multitarget therapy will be also administered during the induction phase. Induction therapy will last for 24 weeks. Patients with severe lupus nephritis who only received multi-target therapy during the same period will be enrolled as the control group.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05863936
Study type Interventional
Source Nanjing University School of Medicine
Contact Jiong Zhang, PhD
Phone 86-25-80862860
Email jiongzhang@live.com
Status Recruiting
Phase Phase 3
Start date April 1, 2023
Completion date December 31, 2024

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