Autologous Cord Blood Cells for Prevention of BPD in Preterm

Status Completed

Clinical Trial Summary

To study the effect of Autologous cord blood cells infusion on prevention of bronchopulmonary dysplasia in very preterm neonates

Clinical Trial Description

We did a randomized, double-blind, placebo-controlled trial to assess effect of one intravenous dose of cord blood MNCs compared with placebo in reducing incidence of BPD in very preterm neonates.We enrolled preterm neonates less than 32 weeks of GA at neonatal intensive care units (NICUs) in Guangdong Women and Children Hospital within the first 24 postnatal hours. Patients were randomly assigned by 1:1 to receive either (5×107cells/kg ACBMNC or normal saline intravenously within 24 hours after birth according to a computer-generated schedule. The primary endpoint was efficacy at 36 GA or discharge home and all analyses were done by intention to prevent.MNCs viability was also tested before transfusion ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04311476
Study type	Interventional
Source	Guangdong Women and Children Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	July 1, 2018
Completion date	January 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04485481` - Single and Multiple Ascending Dose Study of ADX-914 in Healthy Adult Volunteers	Phase 1
Completed	`NCT03473236` - Phase 1A Safety Trial of Inhaled PK10571 (GB002)	Phase 1
Not yet recruiting	`NCT03683953` - The Treatment of Bronchopulmonary Dysplasia by Intratracheal Instillation of Mesenchymal Stem Cells	Phase 1
Recruiting	`NCT05546567` - NOPARK Open Label Extension Study	N/A
Recruiting	`NCT05413226` - Effect of Different Ingestion Doses of Celastrol on Human Sperm Motility	N/A
Recruiting	`NCT05112159` - Study of IPG1094 in Healthy Participants	Phase 1
Completed	`NCT04689035` - A Phase 1 Study in Healthy Volunteers to Evaluate the Safety, Tolerability and Pharmacokinetics of AVLX-144	Phase 1
Completed	`NCT04335045` - Phase I Study of PH100 (Ecklonia Cava Phlorotannins)	Phase 1
Completed	`NCT05037227` - Safety Profile Following Inactivated COVID-19 Vaccine in Healthy Adults Aged >18 Years in Indonesia
Recruiting	`NCT05517291` - DCB Versus Primary Selective Stenting in TASC C/D Femoropopliteal Artery Disease	N/A
Enrolling by invitation	`NCT06446778` - Haemodynamic Mechanisms and Multicentre Prospective Cohort Study of the Pipeline Flow-diverting Device for the Treatment of Intracranial Aneurysms. Evaluation of the Safety and Efficacy of the Pipeline Flow-diverting Device for the Treatment of Intracranial Aneurysms
Recruiting	`NCT04573049` - The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement	Phase 4
Completed	`NCT05585463` - Safety of Acupuncture and Intracutaneous Needles in Pediatric Cancer Patients: a Retrospective Study (ACUSAFE2021)
Completed	`NCT04188821` - Reduction of Seroma and Improvement of QoL in Breast Reconstruction With Tissue Expander	N/A
Completed	`NCT03667430` - Safety Evaluation of Porous Silica in Men	N/A
Completed	`NCT04499482` - Safety and Tolerability of Soy Fiber	N/A
Completed	`NCT03141905` - Sick-Day Protocol to Improve Outcomes in Chronic Kidney Disease	N/A
Completed	`NCT05244161` - A Quasi-experimental Evaluation of the Malezi Program in Tanzania	N/A
Recruiting	`NCT03791372` - Clinical Effect and Safety of Autologous Umbilical Cord Blood Transfusion in the Treatment of Cerebral Palsy	Phase 1
Withdrawn	`NCT04759066` - The HEALiX™ Intubated Patient (IP) Pilot Study	N/A