Clinical Trials Logo

Clinical Trial Summary

Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of several cardiovascular mediators. During cardiogenic shock, upregulation of the vasoconstrictive molecule angiotensin II is a physiologic and potentially life-saving response aimed at maintaining adequate tissue perfusion. As circulating (c)DPP3 is able to effectively cleave angiotensin II, it may represent a novel factor contributing to hemodynamic instability during cardiogenic shock. Recently, a cDPP3-antagonizing antibody called AK1967 (commonly referred to as Procizumab) has been developed. In animal models of cardiogenic- and septic shock, inhibition of cDPP3 by AK1967 resulted in improved cardiac function and survival. Furthermore, AK1967 has shown an excellent safety record in different preclinical studies. In the current study the safety, tolerability and pharmacokinetics/-dynamics of AK1967 will be investigated in healthy male subjects.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06331884
Study type Interventional
Source 4TEEN4 Pharmaceuticals GmbH
Contact Mahir Karakas, MD, PhD, MBA
Phone +4917645862749
Email karakas@4teen4.de
Status Recruiting
Phase Phase 1
Start date March 7, 2024
Completion date July 31, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT06000891 - A Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP7570 Phase 1
Active, not recruiting NCT05997641 - Evaluating the Safety, Tolerability, and Pharmacokinetics of DF-003 in Healthy Subjects Phase 1
Completed NCT06181760 - A Study to Evaluate the Safety of Fenretinide in Healthy Volunteers Phase 1
Recruiting NCT05907382 - Safety, Tolerability of JMKX003002 in Phase 1 Study in Healthy Subjects Phase 1
Completed NCT01952548 - Study Comparing the Pharmacokinetics, Pharmacodynamics, and Safety of K-312 in Healthy Adult Volunteers Phase 1
Recruiting NCT06453824 - SAD Evaluation of Safety, Tolerability, PK, and PD of MDI-2517 in Healthy Participants Phase 1
Completed NCT05431634 - Multiple Dose Study to Determine Safety and Tolerability of ESK-001 in Healthy Participants Phase 1
Completed NCT03046589 - DP13 SAD & MAD in Healthy Male Subjects Phase 1
Recruiting NCT06079541 - Phase 1 Clinical Study of JMKX003142 Tablets Phase 1
Completed NCT05223660 - A Phase I Pharmacokinetics Study for KT07 Capsule Phase 1
Completed NCT01907867 - Pharmacokinetic Profile in Plasma and Epithelial Lining Fluid of Finafloxacin Phase 1
Completed NCT03809052 - A First in Human Study to Evaluate the Safety, Tolerability and PK of GB1211 in Healthy Subjects Phase 1
Completed NCT03853421 - Placebo-controlled Study to Determine the Safety and Tolerability of Subcutaneous Doses of Sevuparin Phase 1
Terminated NCT03307512 - PK and PD Profile of Dance 501 in Healthy, Non-diabetic Subjects With Mild to Moderate Asthma or COPD Phase 2
Completed NCT03685708 - HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's-Tyrosine Kinase Inhibitor (BTK-I) Phase 2
Completed NCT03702231 - Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I) Phase 2
Completed NCT03817346 - Study of Ascending Single Oral Dose of GT-002 in Healthy Volunteers Phase 1
Active, not recruiting NCT01226316 - Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules Phase 1
Completed NCT05451667 - Single-Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of YJ001 in Healthy Volunteers Phase 1
Completed NCT02029482 - Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-128800 in Healthy Subjects Phase 1