Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery

Roux-en-Y Gastric Bypass Clinical Trial

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Official title:

Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02068001
• Other study ID #: NL45837.081.13
• Status: Active, not recruiting
• Phase: N/A
• First received: February 5, 2014
• Last updated: May 22, 2017
• Start date: July 2014

Study information

• Verified date: May 2017
• Source: Wageningen University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 100
• Est. primary completion date: September 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital

Exclusion Criteria:

• Lack of appetite

• Having difficulties swallowing/eating

• Being a vegetarian

• Allergic to food product used as stimuli in the study

Related Conditions & MeSH terms

• Roux-en-Y Gastric Bypass

Intervention

Procedure:
• Roux-en-Y Gastric Bypass

Locations

Country	Name	City	State
Netherlands	Rijnstate Hospital	Arnhem	Gelderland
Netherlands	Gelderse Vallei Hospital	Ede	Gelderland
Netherlands	Wageningen University	Wageningen	Gelderland

Sponsors (2)

Lead Sponsor	Collaborator
Wageningen University	Rijnstate Hospital

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Descriptives	General subject characteristics, e.g. age, gender, restrained eating score and other lifestyle and medical parameters.; For the subset of 30 patients that participate in the fMRI measurements: disinhibition scores will be assessed.	Before surgery
Other	Appetite ratings	In a subset of 30 participants.	During fMRI measurements, i.e., before and two months after surgery
Other	Olfactory performance	The Sniffin' Sticks test will be used to assess olfactory performance in the subset of 30 participants that will participate in the fMRI measurements. The sum-score of threshold, discrimination and identification tests will be used to determine if a participant is normosmic. A score of > 30 indicates a participant is normosmic.	At each fMRI measurement, i.e., before and two months after surgery
Other	Development of BMI		Before and after surgery
Primary	Development of food preferences after Roux-en-Y gastric bypass surgery	Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery.	Participants will be followed for two years after they undergo surgery
Primary	Change in brain reward response to food cues	Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants.	Before and 2 months after surgery
Secondary	Plasma levels of endocannabinoids and satiety hormones	Two weeks before and two months after Roux-en-Y gastric bypass surgery, fasted plasma levels of endocannabinoids, ghrelin, leptin, adiponectin and Glucagon-Like Peptide will be assessed in a subset of 30 participants.	Before and 2 months after surgery