Does the Fecal Microbiome Influence Rotarix Immunogenicity

Status Completed

Clinical Trial Summary

This is a proposal for a nested case‐control study within an ongoing rotavirus vaccine immunogenicity clinical trial Karachi, Pakistan. The primary study aim is to compare the fecal microbiota composition and diversity of infants who do (control) and do not (case) demonstrate immune seroconversion to rotavirus vaccination. The infants will be matched for vaccination dose, age and breast‐feeding practices.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Dysbiosis
Intestinal Bacteria Flora Disturbance
Reaction - Vaccine Nos
Rotavirus Infections

Clinical Trial Details

NCT number	NCT02220439
Study type	Observational
Source	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Contact
Status	Completed
Phase	N/A
Start date	September 2013
Completion date	November 2013

View Details

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