PRP for Rotator Cuff Tears

Status Not yet recruiting

Clinical Trial Summary

Regenerative medicine, specifically orthobiologics is a hot topic in the community and in Sports Medicine. Riding the hype curve of a new treatment can be great when offering new procedures to patients. However, as the excitement regarding potential benefits of orthobiologics grows, it is valuable to grow the body of literature on their safety and efficacy in various musculoskeletal conditions. Furthering the body of data regarding which musculoskeletal conditions may benefit most from these treatments and which may not can help guide physicians on when to incorporate orthobiologics into clinical practice. More robust data can help physicians guide patients and patient expectations when discussing treatment options. Platelet rich plasma (PRP) in musculoskeletal medicine is most commonly used to treat tendinopathies and degenerative joint disease. The American Medical Society for Sports Medicine released a position statement in November of 2021 summarizing meta-analysis and systemic review data evaluating efficacy and major adverse events of PRP for tendinopathy and osteoarthritis1. At this time, the most robust data exists for lateral epicondylopathy as multiple randomized controlled trials demonstrate positive response to PRP. Gluteus medius tendinopathy and plantar fasciaopathy similarly have positive data. In Achilles tendinopathy, well designed RCTs have shown no difference between PRP and saline injections. These data should help guide physicians in responsible use and patient counseling. Data from Hurley et al. suggest PRP may augment rotator cuff repair with improved rates of healing and reduced overall pain. However, there are limited high quality studies on the efficacy of PRP alone in partial rotator cuff tear. Partial rotator cuff tear is a common musculoskeletal complaint that can be treated with conservative measures such as physical therapy and corticosteroid injection. It can also be treated with surgical intervention if those modalities provide incomplete or inadequate pain relief and functional restoration. This study aims to evaluate if PRP is an efficacious treatment modality for partial rotator cuff tear.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06422390
Study type	Observational
Source	Scripps Clinic
Contact	Emily Martin, MBt
Phone	858-554-7011
Email	martin.emily2@scrippshealth.org
Status	Not yet recruiting
Phase
Start date	June 2024
Completion date	July 2025

View Details

See also
Status	Clinical Trial	Phase
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Recruiting	`NCT06055478` - Effect of Suprascapular Nerve Block and Axillary Nerve Block After Arthroscopic Rotator Cuff Repair	N/A
Completed	`NCT04552925` - Exercises With Electromyographic Biofeedback in Conservative Treatment of Massive Rotator Cuff Tears	N/A
Not yet recruiting	`NCT06032416` - DenCT Shoulder Bone Quality Evaluation	N/A
Not yet recruiting	`NCT04047745` - Post-operative Exparel Study Following Rotator Cuff Repair	N/A
Completed	`NCT01029574` - Platelet Rich Plasma on Rotator Cuff Repair	Phase 3
Not yet recruiting	`NCT05817578` - Profiling the RCRSP Patient: a Pain Phenotype Classification Algorithm
Not yet recruiting	`NCT05670080` - Does MI Have a Therapeutic Role in Arthroscopic Rotator Cuff Repair?	N/A
Suspended	`NCT04421417` - The Effect of Microfracture Procedure on Rotator Cuff Tendon Healing	N/A
Recruiting	`NCT06156423` - Investigation of the Effect of Motor Control Exercises in Patients Undergoing Rotator Cuff Surgery	N/A
Completed	`NCT06145815` - Machine Learning Predictive Model for Rotator Cuff Repair Failure
Not yet recruiting	`NCT05009498` - Vitamin D3 Supplementation for Vitamin D Deficiency in Rotator Cuff Repair Surgery	N/A
Not yet recruiting	`NCT04538001` - Safety and Efficacy of Rotator Cuff Function Restoration Balloon in Irreparable Rotator Cuff Tear	N/A
Terminated	`NCT04855968` - The Effect of Mindfulness/Meditation on Post-operative Pain and Opioid Consumption	N/A
Completed	`NCT04594408` - Tranexamic Acid to Improve Arthroscopic Visualization in Shoulder Surgery	Phase 4
Completed	`NCT04710966` - Comparison Between Arthroscopic Debridement and Repair for Partial-thickness Rotator Cuff Tears	N/A
Recruiting	`NCT06192459` - Effect of the Muscle Strength and Range of Motion Training for Post-platelet Rich Plasma Injection in People With Rotator Cuff Partial Tear	N/A
Recruiting	`NCT05925881` - Lower Trapezius Transfer vs Bridging Reconstruction	N/A
Recruiting	`NCT05988541` - Rotator Cuff Integrity and Clinical Outcomes 5 Years After Repair.	N/A
Not yet recruiting	`NCT04587037` - A Clinical Study Comparing Superior Capsule Reconstruction Using Different Graft for Irreparable Rotator Cuff Tear	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.