Rosacea Clinical Trial - Analysis of the Microbiome in Rosacea

Status Recruiting

Clinical Trial Summary

The skin and gut microbiome of rosacea patients differs from individuals without rosacea and that the microbiome suffers from unique derangements in rosacea patients following antibiotic therapy. This study was proposed to examine microbial signatures of the skin and gut microbiome in patients with moderate to severe rosacea and to identify differences between microbe communities in patients with rosacea and volunteers without rosacea using 16S ribosomal ribonucleic acid (rRNA) polymerase chain reaction (PCR) amplification, sequencing and computational phylogenetics and to assess alterations in the gut and skin microbiota of patients with moderate to severe rosacea in response to varying formulations of antimicrobial treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Rosacea

Clinical Trial Details

NCT number	NCT04108897
Study type	Interventional
Source	Johns Hopkins University
Contact	Ruizhi Wang
Phone	410-502-7546
Email	rwang@jhmi.edu
Status	Recruiting
Phase	Early Phase 1
Start date	September 17, 2019
Completion date	September 2026

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05597462` - Impact of DFD-29 on Microbial Flora of Healthy, Adult Human Subjects When Administered Over 16 Weeks	Phase 1
Completed	`NCT02601963` - Safety and Efficacy Study of a Topical Minocycline Foam in Patients With Papulopustular Rosacea	Phase 2
Completed	`NCT02249065` - Mirvaso in Use Study	Phase 4
Completed	`NCT02292797` - Assessment of the Rosacea Prevalence in the General Population	N/A
Completed	`NCT01659853` - Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea	Phase 3
Completed	`NCT01426269` - Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo	Phase 4
Completed	`NCT00991198` - The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage	Phase 2
Terminated	`NCT04336163` - Skin Imaging to Inform Laser Treatments	N/A
Completed	`NCT03872050` - Deep Phenotyping of Rosacea and Migraine
Active, not recruiting	`NCT06033352` - Potassium-titanyl Phosphate (KTP) Laser vs KTP Laser and Ivermectin Cream for Facial Rosacea	Phase 2
Completed	`NCT03263273` - Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea	Phase 2
Completed	`NCT04508660` - CGB-400 for the Reduction of Facial Redness	Phase 1
Completed	`NCT04508205` - CGB-400 for the Reduction of Facial Redness and Bumps and Blemishes	Phase 1
Completed	`NCT05094700` - A Study of a Polymeric Surfactant Technology Cleanser in Sensitive Skin Participants	N/A
Active, not recruiting	`NCT03211585` - EVALUATION OF THE EFFECT OF THE PERFECTA V-BEAM LASER ON ROSACEA	N/A
Completed	`NCT02576860` - Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle	Phase 3
Completed	`NCT02576847` - Study to Evaluate the Long-term Safety of a Once-Daily Omiganan Topical Gel	Phase 3
Completed	`NCT02637232` - Mirvaso® Utilisation and Patient Satisfaction Evaluation (MUSE)
Completed	`NCT02583009` - A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Rosacea	Phase 2
Completed	`NCT01993446` - A Safety and Efficacy Study of DRM02 in Subjects With Rosacea	Phase 2