Genetic Basis of Rosacea Study (Control)

Rosacea Clinical Trial

Official title:

Expansion Arm of Papulopustular Rosacea Gene Expression Profiling to Include Normal Individuals as Anatomic Site Specific Controls

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02749786
• Other study ID #: 22419
• Status: Completed
• Phase: N/A
• Start date: January 21, 2016
• Est. completion date: August 1, 2016

Study information

• Verified date: September 2019
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. It it considered to be a syndrome encompassing various combinations of cutaneous signs including flushing, erythema, telangiectasia, papules, edema, ocular lesions, and rhinophyma. The exact etiology of cutaneous rosacea is unknown but is characterized by persistent vasodilation, increased vascular permeability, and vascular hyper-reactivity of the microcirculation of the central part of the face. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigator hopes to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: August 1, 2016
• Est. primary completion date: August 1, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria include:

1. Fitzpatrick skin type II or III

2. Age greater than or equal to 18 years

3. Individuals without a history of rosacea

Exclusion criteria include:

1. Women who are pregnant or lactating

2. Use of topical prescription medications or procedures to the face within one month of enrollment

3. Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)

Related Conditions & MeSH terms

• Rosacea

Intervention

Other:
• Skin Biopsy
Skin biopsies will be performed via the Keys punch technique from normal facial skin.

Locations

Country	Name	City	State
United States	Stanford Dermatology	Redwood City	California

Sponsors (1)

Lead Sponsor	Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gene expression profile of papulopustular rosacea compared to normal skin and skin from individuals without rosacea.		Up to 2 years