Rosacea Clinical Trial
Official title:
Investigation of Relation Between Demodex Density With Immune Response and Oxidative Stress in Rosacea Patients
Aim of study is to determine reactive oxygen products and antioxidant capacity with rosacea patients; to measure metalloproteinase level and inflammatory markers of immune response and investigate their corelation with demodex infestation and also investigate the role of photoaging and sebum secretion in rosacea.
Rosacea is a common and chronic inflammatory disease characterized by facial erythema,
papule, pustule and telangiectasia. Ultraviolet, Demodex mite, oxidative stress and
antioxidant system disorders are emphasized in increased inflammation seen in rosacea.
The aim of our study was to evaluate the status of oxidative stress, matrix
metalloproteinase (MMP) and inflammatory markers in systemic circulation, their relationship
with demodex density and investigate the role of photoaging and sebum secretion in rosacea.
Forty patients with rosacea and age, gender and skin phenotype matched 40 healthy volunteers
were enrolled in the study. Reflectance confocal microscopy (RCM) was used to calculate
facial demodex density. The number of demodex, follicle, the number of mite per follicle,
the number of infested follicle and the number of mite per infested follicle were calculated
with RCM.
Photoaging severity and facial sebum levels were also assessed. Total oxidant capacity
(TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), paraoxonase-1
(PON-1), aryl esterase (ARES), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α),
interleukin-1beta (IL-1β), matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-9
(MMP-9) levels in venous blood were measured.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05597462 -
Impact of DFD-29 on Microbial Flora of Healthy, Adult Human Subjects When Administered Over 16 Weeks
|
Phase 1 | |
| Completed |
NCT02601963 -
Safety and Efficacy Study of a Topical Minocycline Foam in Patients With Papulopustular Rosacea
|
Phase 2 | |
| Completed |
NCT02249065 -
Mirvaso in Use Study
|
Phase 4 | |
| Completed |
NCT02292797 -
Assessment of the Rosacea Prevalence in the General Population
|
N/A | |
| Completed |
NCT01659853 -
Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea
|
Phase 3 | |
| Completed |
NCT01426269 -
Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo
|
Phase 4 | |
| Completed |
NCT00991198 -
The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage
|
Phase 2 | |
| Terminated |
NCT04336163 -
Skin Imaging to Inform Laser Treatments
|
N/A | |
| Recruiting |
NCT04108897 -
Analysis of the Microbiome in Rosacea
|
Early Phase 1 | |
| Completed |
NCT03872050 -
Deep Phenotyping of Rosacea and Migraine
|
||
| Active, not recruiting |
NCT06033352 -
Potassium-titanyl Phosphate (KTP) Laser vs KTP Laser and Ivermectin Cream for Facial Rosacea
|
Phase 2 | |
| Completed |
NCT03263273 -
Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea
|
Phase 2 | |
| Completed |
NCT04508205 -
CGB-400 for the Reduction of Facial Redness and Bumps and Blemishes
|
Phase 1 | |
| Completed |
NCT04508660 -
CGB-400 for the Reduction of Facial Redness
|
Phase 1 | |
| Completed |
NCT05094700 -
A Study of a Polymeric Surfactant Technology Cleanser in Sensitive Skin Participants
|
N/A | |
| Active, not recruiting |
NCT03211585 -
EVALUATION OF THE EFFECT OF THE PERFECTA V-BEAM LASER ON ROSACEA
|
N/A | |
| Completed |
NCT02576847 -
Study to Evaluate the Long-term Safety of a Once-Daily Omiganan Topical Gel
|
Phase 3 | |
| Completed |
NCT02637232 -
Mirvaso® Utilisation and Patient Satisfaction Evaluation (MUSE)
|
||
| Completed |
NCT02576860 -
Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle
|
Phase 3 | |
| Completed |
NCT02583009 -
A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Rosacea
|
Phase 2 |