Ropivacaine Clinical Trial
Official title:
The Optimal Dosage of Ropivacaine for Arthroscopic Knee Surgery
Verified date | August 2023 |
Source | Shengjing Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Fast-track Surgery (FTS ) refers to the application of various proven effective methods in perioperative period to reduce stress and complications and accelerate the recovery of patients.Nowadays, FTS has been successfully applied in clinical practice."FTS" truly embodies the concept of "patient-centered" and the direction of medical development. Lower limb joint damage (the meniscus, and patellar ligament, etc.) is the joint movement orthopedic common disease, often characterized by joint swelling, pain, sports relaxation instability, thigh muscle atrophy, most can't continue to pursue the original movement, even unbend and flexor limited activity, result in patients with walking difficulties, serious impact on the patient's quality of life.Practice has proved that minimally invasive surgery under arthroscopy is the best way to treat such injuries. According to literature reports, the average hospital stay after arthroscopy is 5~7 days, while successful application of FTS can shorten it to 2~3 days. Anesthesia plays an important role in the process of FTS.Compared with general anesthesia, intra-spinal anesthesia can effectively reduce the incidence of postoperative complications in patients, such as ventilator-related lung injury, deep vein thrombosis, cardiovascular and cerebrovascular accidents, and acute renal failure.Ropivacaine is a long-acting amide local anesthetic. Compared with bupivacaine, it is more and more widely used in spinal anesthesia due to its advantages of lower degree of motor nerve block and weaker toxicity to central nervous system and cardiac.However, the optimal dosage of ropivacaine for arthroscopic surgery is still unclear. Conventional dosage makes patients unable to move 2-4h after surgery and unable to urinate autonomically. Therefore, this study aims to optimize the dosage of ropivacaine for spinal anesthesia and enable patients to recover motor function at an early stage.
Status | Completed |
Enrollment | 115 |
Est. completion date | June 1, 2023 |
Est. primary completion date | June 1, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Patients undergoing elective arthroscopic knee surgery - ASA: grade I to III Exclusion Criteria: - There are contraindications to spinal anesthesia - Allergic to local anesthetics - Patient refused |
Country | Name | City | State |
---|---|---|---|
China | Shengjing Hospital | Shengyang | Liaoning |
Lead Sponsor | Collaborator |
---|---|
Yanchao Yang |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the median effective dose (ED) of ropivacaine in knee arthroscopic surgery | The primary outcome of this present study was the median effective dose (ED) of ropivacaine in knee arthroscopic surgery to allow immediate postoperative mobilization as well as adequate anesthesia during surgery.The up and down method as described by Dixon and Massey was used.This is a sequential allocation model in which patients received a dose of ropivacaine according to the outcome of the preceding patient. A starting dose of the test sequence was set to 12.5 mg ropivacaine .The dose of ropivacaine in the next patient was increased or decreased according to the experimental results of the previous patient, and the adjusted dose was 0.5mg. | from preoperative to postoperative 24 hours |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03688269 -
Minimal Effective Concentration (EC90) of Ropivacaine
|
Phase 3 | |
Not yet recruiting |
NCT06145945 -
Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy
|
N/A | |
Recruiting |
NCT06430112 -
Liposomal Bupivacaine vs Ropivacaine for TAPBs
|
Phase 3 | |
Recruiting |
NCT02125994 -
Effect of 0.5% vs 0.375% Ropivacaine on Autonomous Nervous System
|
N/A | |
Not yet recruiting |
NCT04763434 -
Dexamethasone and Dexmedetomidine as Adjuvants to Ropivacaine in Ultrasound-guided Multilevel Thoracic Paravertebral Block for Lobectomy: A Prospective, Randomized, Triple-blind Study
|
Phase 4 | |
Completed |
NCT05995301 -
Comparative Study on Postoperative Analgesia With Transversus Abdominis Plane Block to Local Anesthetic Infiltration With Ropivacaine in Laparoscopic Abdominal Surgery
|
N/A | |
Completed |
NCT05979558 -
Caudal Ropivacaine With or Without Dexmedetomidine for Post Operative Analgesia
|
N/A | |
Recruiting |
NCT02838329 -
Labour Epidural Top-up With Warmed Ropivacaine
|
N/A | |
Completed |
NCT02344264 -
Effect of Nervus Cutaneous Femoris Lateralis-Blockade on Moderate Pain Responders After Total Hip Arthroplasty
|
Phase 4 | |
Not yet recruiting |
NCT05824338 -
Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery
|
Early Phase 1 | |
Recruiting |
NCT04879004 -
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
|
N/A | |
Completed |
NCT03563963 -
Ropivacaine vs Lidocaine in the Endotracheal Tube Cuff on Post-Operative Sore Throat
|
N/A | |
Recruiting |
NCT06379490 -
Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures
|
Phase 3 | |
Completed |
NCT03265223 -
Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain
|
Phase 4 |