NCT04432415 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Deutsch A
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. Spec Care Dentist. 2016 Mar-Apr;36(2):85-92. doi: 10.1111/scd.12153. Epub 2015 Dec 21.
Richards D
Fluoride has a beneficial effect on root caries. Evid Based Dent. 2009;10(1):12. doi: 10.1038/sj.ebd.6400627.
Sequeira-Byron P, Lussi A
Prevention of root caries. Evid Based Dent. 2011;12(3):70-1. doi: 10.1038/sj.ebd.6400805.
Tan HP, Lo EC, Dyson JE, Luo Y, Corbet EF
A randomized trial on root caries prevention in elders. J Dent Res. 2010 Oct;89(10):1086-90. doi: 10.1177/0022034510375825. Epub 2010 Jul 29.
Twetman S, Keller MK
Fluoride Rinses, Gels and Foams: An Update of Controlled Clinical Trials. Caries Res. 2016;50 Suppl 1:38-44. doi: 10.1159/000439180. Epub 2016 Apr 22. Review.
Zhang W, McGrath C, Lo EC, Li JY
Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. Caries Res. 2013;47(4):284-90. doi: 10.1159/000346620. Epub 2013 Feb 5.

Comparison of the Efficacy of Silver Diamine Fluoride Solution and Sodium Fluoride Varnish for the Prevention and Arrest of Root Caries in a Group of Older Adults

Details for clinical trial NCT04432415

Clinical trial NCT04432415 - References