Rolandic Epilepsy Clinical Trial
In clinical practice language impairment is frequently reported in association with
nocturnal epileptiform activity. There is a spectrum of epileptic conditions that are
characterized by nocturnal epileptiform activity. From mild to severe this spectrum
involves: Rolandic epilepsy (RE), nocturnal frontal lobe epilepsy (NFLE), Landau-Kleffner
syndrome (LKS) and electrical status epilepticus during slow wave sleep (ESES). The exact
characteristic of the relationship between nocturnal epileptiform activity and language
impairment is yet to be explored. The investigators suggest that nocturnal epileptiform EEG
discharges and nocturnal epileptic seizures during development will cause diseased neuronal
networks that involve language. The diseased neuronal networks are less efficient compared
with normal neuronal networks.
Objective: Identification of a diseased neuronal network characteristic in children with
nocturnal epileptiform activity, which can explain language impairment in these children.
For this the investigators will use functional magnetic resonance imaging (MRI) to analyse
brain activity and diffusion weighted MRI to investigate white matter connectivity.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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