Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium in Emergency Department

Rocuronium Clinical Trial

Official title:

Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium Priming Technique in Patients Registering to the Emergency Department and With Indication of Elective Intubation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05343702
• Other study ID #: nisik
• Status: Completed
• Start date: July 15, 2021
• Est. completion date: January 15, 2022

Study information

• Verified date: September 2023
• Source: Ankara City Hospital Bilkent
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Airway management and advanced airway management are the issues that are applied every day in emergency services and that the emergency physician should know best. Rapid sequential intubation is one of the most frequently used techniques in advanced airway management. However, anesthetic agents and paralytic agents have some concerns with some side effects. In our study, This study aimed to compare the effect of standard rapid sequential intubation protocol and application of rocuronium priming technique on the procedure time and hemodynamic profile.

Description:

This study is a prospective, observational and randomized study conducted between 15.07.2021 and 01.12.2021 in Ankara City Hospital Emergency Medicine Clinic, which is a third-level emergency department with approximately 450,000 patient admissions per year. Patients who applied to the emergency department and needed rapid sequential intubation were included in our study. Randomization was done according to the order of arrival of the cases. The demographic characteristics of the patients included in the study and the presence of diabetes mellitus were recorded. Routine rapid sequential intubation was performed in the standard group. In the priming group, 10% of the rocuronium dose was administered approximately 3 minutes before the induction agent. Intubation time, amount of drug used, vital signs before and after intubation, and end tidal carbon dioxide level to confirm intubation were recorded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 52
• Est. completion date: January 15, 2022
• Est. primary completion date: December 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Be over the age of 18

• Need for advanced airway

• To give consent or consent to participate in the study consent of relatives of those who are unable to give

Exclusion Criteria:

• Have an indication of a crush (rescue) airway

• Have one of the difficult airway predictor Look, Evaluate, Obstruction, Neck mobility criteria

• maxillofacial anomaly or trauma

• detected during laryngoscopy with a cormack-lehane score of 3 and 4 patients

• Those who have inconveniences in applying ketamine to the clinic of the patient

• with a rocuronium or ketamine allergy

Related Conditions & MeSH terms

• Emergencies
• Rocuronium

Intervention

Drug:
• priming with rocuronium
Following induction (paralysis after onset of the induction effect) in routine rapid sequence intubation protocols While paralysis is applied, it is aimed to shorten the half-life of rocuronium by administering a subparalytic dose of rocuronium approximately 3-5 minutes before induction in the priming technique

Locations

Country	Name	City	State
Turkey	Ankara Bilkent Sehir Hastanesi	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Ankara City Hospital Bilkent

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	intubation time	when successful endotracheal intubation is performed after induction	ten minutes
Primary	blood pressure systolic and diastolic	mmhg	ten minutes
Primary	heart rate	beats/minute	ten minutes
Secondary	indirect perfusion	Indirect tissue perfusion interpretation with endtidal carbon dioxide levels	ten minutes