Clinical Trials Logo

Clinical Trial Summary

Background: Residual pulmonary regurgitation following repair of tetralogy of Fallot, in particular the use of a transannular patch, has been shown to correlate with the development of right ventricular dysfunction. Optimal timing of pulmonary valve replacement, therefore, is important to preserve right ventricular function. Several recent studies suggested that a threshold of right ventricular end-diastolic volume for intervention, in order to preserve the likelihood of adequate reverse remodeling, is in the region of 150 to 200 ml/m2 body surface area. However, there is evidence that right ventricular function does not always recover following pulmonary valve replacement even if the end-diastolic volume is below this cut-off.

In addition, previous studies suggested that early dysfunction may be present before symptoms occur. However, early dysfunction is difficult to assess.

Methods: Analysis of right ventricular function by pressure-volume loops has been extensively evaluated in experimental studies and is generally considered the optimal way to quantify right ventricular function.

By recording a family of pressure-volume loops during reduction of preload, achieved by temporary balloon occlusion of the inferior caval vein, the contractility can be calculated by the slope of the endsystolic pressure-volume relation (elastance). Changes of contractility following dobutamine infusion could be noted by changes of elastance. The increase of the slope during dobutamine demonstrates the contractility reserve of the right ventricle.

Purpose: To evaluate the right ventricular contractility reserve to determine early ventricular dysfunction after repair of tetralogy of Fallot.


Clinical Trial Description

n/a


Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic


Related Conditions & MeSH terms


NCT number NCT00557934
Study type Interventional
Source University Hospital Tuebingen
Contact
Status Completed
Phase N/A
Start date October 2007
Completion date September 2008

See also
  Status Clinical Trial Phase
Completed NCT03183414 - Right Ventricular Dysfunction in Cardiac Surgery Patients
Recruiting NCT04764032 - Right Ventricular Dysfunction in Ventilated Patients With COVID-19
Not yet recruiting NCT05188222 - Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery Phase 4
Not yet recruiting NCT06002321 - Right Ventricular Dysfunction in Chronic Heart Failure
Completed NCT05948332 - Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
Recruiting NCT03309852 - Emergency Department Assessment of Right Ventricular Function and Size in the Post Cardiac Arrest Patient
Recruiting NCT05583461 - Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS N/A
Completed NCT03438825 - PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients
Active, not recruiting NCT01230294 - New Echocardiographic Methods for Right Ventricular Function. N/A
Completed NCT04694378 - Relationship Between Strain and Stroke Volume in Cardiac Surgery
Not yet recruiting NCT04167241 - Right Ventricle Function After Major Right Lung Resection
Recruiting NCT03013075 - General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function Phase 4
Completed NCT06197256 - Cardiac Dysfunction in Critically Ill Covid-19 Patients
Completed NCT03301571 - Right Ventricular Echocardiography in caRdiac SurgEry N/A
Recruiting NCT05860504 - Acute Cardiac Dysfunction in Critical Illnes
Completed NCT01093001 - Tricuspid Regurgitation Study Phase 4
Recruiting NCT05758194 - Mitigating Post-Op RV Dysfunction After LVAD Implantation N/A
Not yet recruiting NCT05768230 - Using TEE to Evaluate the Effect of Levosimendan on Patients With ARDS Associated With RVD During MV Phase 2/Phase 3
Not yet recruiting NCT05620992 - Evaluation of Right Ventricular Function Post Mitral Valve Operations
Completed NCT03806582 - Effect of a Higher Blood-pressure on Right Ventricular Function Phase 4