Rhinitis, Allergic, Nonseasonal Clinical Trial
Official title:
Individual Factors in Nasal Irritant Sensitivity
NCT number | NCT00041821 |
Other study ID # | 10424-CP-001 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | July 18, 2002 |
Last updated | March 22, 2006 |
Start date | September 2000 |
This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).
Status | Completed |
Enrollment | 64 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 69 Years |
Eligibility |
Inclusion Criteria: - Non-smokers - 18-69 years of age - With or without allergic rhinitis (hay fever) - In good general health and with no prior history of asthma |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind
Country | Name | City | State |
---|---|---|---|
United States | Upper Airway Biology Laboratory | Richmond | California |
Lead Sponsor | Collaborator |
---|---|
National Institute of Environmental Health Sciences (NIEHS) |
United States,
Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9. — View Citation
Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40. — View Citation
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