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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00041821
Other study ID # 10424-CP-001
Secondary ID
Status Completed
Phase N/A
First received July 18, 2002
Last updated March 22, 2006
Start date September 2000

Study information

Verified date March 2006
Source National Institute of Environmental Health Sciences (NIEHS)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).


Recruitment information / eligibility

Status Completed
Enrollment 64
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 69 Years
Eligibility Inclusion Criteria:

- Non-smokers

- 18-69 years of age

- With or without allergic rhinitis (hay fever)

- In good general health and with no prior history of asthma

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind


Intervention

Procedure:
Nasal irritation thresholds and irritant provocation


Locations

Country Name City State
United States Upper Airway Biology Laboratory Richmond California

Sponsors (1)

Lead Sponsor Collaborator
National Institute of Environmental Health Sciences (NIEHS)

Country where clinical trial is conducted

United States, 

References & Publications (2)

Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9. — View Citation

Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40. — View Citation

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