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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis — Regulate-RA  

Rheumatoid Arthritis Clinical Trial

Official title:
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Activity of Single Ascending Doses of SBT777101 in Subjects With Rheumatoid Arthritis

Clinical Trial Summary

This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown.

Clinical Trial Description

The study evaluates the safety and effects of a novel regulatory CARTreg cell-based autoimmune and inflammatory disease therapy for the treatment of rheumatoid arthritis. The therapy is an autologous (using the patient's own cells) Treg cell therapy that targets proteins in the inflamed, disease-associated tissue, with the aim to dampen inflammation and restore balance to the immune system. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06201416
Study type Interventional
Source Sonoma Biotherapeutics, Inc.
Contact Sabrina Fox-Bosetti, MPH
Phone 415-992-6245
Email clinicaloperations@sonomabio.com
Status Recruiting
Phase Phase 1
Start date March 6, 2024
Completion date March 2026
View Details
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