Effect of Quadriceps Muscle on Physical Outcome Measures in Women With Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

Official title:

Evaluation of Morphologic Parameters of Quadriceps Muscle Predicting Disease Activity, Physical Performance and Quality of Life in Women With Rheumatoid Arthritis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06197074
• Other study ID #: 2023/8
• Status: Recruiting
• Start date: December 25, 2023
• Est. completion date: December 25, 2025

Study information

• Verified date: January 2024
• Source: Afyonkarahisar Health Sciences University
• Contact: ERDAL HORATA, PhD
• Phone: +905056092631
• Email: erdalhorata[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Studies have reported that individuals with Rheumatoid Arthritis have a smaller muscle cross-sectional area, pennation angle and muscle thickness than healthy controls. Sarcopenia may decrease physical performance and quality of life in individuals with RA. Therefore, morphologic changes in the quadriceps femoris muscle due to sarcopenia may help us to gain insight into physical function and quality of life. This study aims to evaluate the predictive capacity of morphologic characteristics of the quadriceps femoris muscle for disease activity, physical performance, and quality of life in women with Rheumatoid Arthritis.

Description:

Studies have reported that individuals with Rheumatoid Arthritis have a smaller muscle cross-sectional area, pennation angle and muscle thickness than healthy controls. Sarcopenia may decrease physical performance and quality of life in individuals with RA. Therefore, morphologic changes in the quadriceps femoris muscle due to sarcopenia may help us to gain insight into physical function and quality of life. This study aims to evaluate the predictive capacity of morphologic characteristics of the quadriceps femoris muscle for disease activity, physical performance, and quality of life in women with Rheumatoid Arthritis.

Within the scope of the study, the morphological characteristics of the quadriceps muscle of the participants will be evaluated by a Physical Medicine and Rehabilitation specialist physician via ultrasound. After appropriate visualization, the image will be captured and saved in JPEG format, and will be exported to the ImageJ program for further analysis and evaluations will be performed by an anatomist. Assessments of quality of life and physical performance will be made by a physiotherapist involved in the study.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 102
• Est. completion date: December 25, 2025
• Est. primary completion date: December 25, 2025
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• 18-60 years old

• Female participants with a confirmed diagnosis of RA for at least 3 years according to the 2010 American College of Rheumatology (ACR) criteria

• Presence of sarcopenia

Exclusion Criteria:

• Presence of fractures, burns or lesions in the area to be measured

• Presence of any neuromuscular, cardiovascular or metabolic disease,

• Individuals with knee endoprosthesis,

• Inability to walk

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Rheumatoid Arthritis

Intervention

Other:
• Ultrasound assessment
The morphological characteristics of the quadriceps muscle of the participants will be assessed using ultrasound.

Locations

Country	Name	City	State
Turkey	Afyonkarahisar Health Sciences University	Afyonkarahisar

Sponsors (1)

Lead Sponsor	Collaborator
Afyonkarahisar Health Sciences University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Vastus lateralis muscle length	Vastus Lateralis muscle length will be measured bilaterally by Ultrasound.	10 minutes