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Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders — EASi-RAIR  

Rheumatoid Arthritis Clinical Trial

Official title:
A Pilot Proof of Concept Study of the Effects of Administration of a Short Chain Fatty Acid (SCFA) Supplement in Rheumatoid Arthritis Inadequate Responders (EASi-RAIR)

Clinical Trial Summary

This study is a pilot, proof of concept study to determine the effects of administering an oral short-chain fatty acid (SCFA) supplement to Rheumatoid Arthritis (RA) patients with inadequate response to methotrexate (MTX). The study will include up to 35 participants to obtain a sample size of at least 25 participants taking the oral supplement. The researchers hypothesize that oral SCFA will change the participants' gut microbiome and regulatory immune responses. Clinical data to assess for adverse events, stool, urine samples and peripheral blood will be collected at baseline, 1 month, and with an optional 2 month time-point. Fecal microbiome will be analyzed. Adaptive immune responses will be analyzed from participant blood samples.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05718583
Study type Interventional
Source NYU Langone Health
Contact Rebecca B. Blank, MD, PhD
Phone 212-598-6149
Email Rebecca.blank@nyulangone.org
Status Recruiting
Phase N/A
Start date February 1, 2023
Completion date February 1, 2025
View Details
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