The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

Official title:

The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04439682
• Other study ID #: 97132852/050.01.04/
• Status: Recruiting
• Phase: N/A
• Start date: July 17, 2020
• Est. completion date: June 17, 2021

Study information

• Verified date: June 2020
• Source: Gazi University
• Contact: Songul B Yentur
• Phone: 0424 237 8282
• Email: songulbaglan23[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.

Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. completion date: June 17, 2021
• Est. primary completion date: September 17, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Patients who were aged between 18-65 years,

• Patients who got diagnosed according to American College of Rheumatology criteria

• Patients who were being followed at Firat University Department of Rheumatology

Exclusion Criteria:

• Patients who had regular exercise habits, malignancy, pregnancy, incorporation,

• Patients who took anti-TNF treatment

• Patients who had changes of medical treatment in last 3 months

• Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity

• Patients who had cardiac symptoms according to New York Heart Association

• Patients who had dysfunction that can prevent physical activity

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Rheumatoid Arthritis

Intervention

Other:
• Aerobic exercise
Aerobic exercise will be performed to all participants for a single session. Maximum heart rate was calculated for each subject (220 - age) and a heart rate monitor (Polar FT 100, China) will be used to follow subjects' heart rate during aerobic exercise.

Locations

Country	Name	City	State
Turkey	Songul Baglan Yentur	Elazig

Sponsors (1)

Lead Sponsor	Collaborator
Gazi University

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Grimsholm O, Rantapää-Dahlqvist S, Dalén T, Forsgren S. BDNF in RA: downregulated in plasma following anti-TNF treatment but no correlation with inflammatory parameters. Clin Rheumatol. 2008 Oct;27(10):1289-97. doi: 10.1007/s10067-008-0910-4. Epub 2008 May 17. — View Citation

Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res. 2015 Jan;60:56-64. doi: 10.1016/j.jpsychires.2014.10.003. Epub 2014 Oct 12. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Irisin	Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.	1 minute
Secondary	BDNF, VEGF, TNF- a, IL-6, IL-1ß and a- Klotho	Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.	1 minute