Rheumatoid Arthritis Clinical Trial
— MICROPOREOfficial title:
Study of the Articular Microbiota in Rheumatoid Arthritis.
Verified date | August 2019 |
Source | University Hospital, Bordeaux |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The cause of rheumatoid arthritis (RA) remains unknown, although major advances have been
done these last ten years in the comprehension of its pathophysiology.
The aim of this study is to described a synovial microbiota specific for rheumatoid
arthritis.
Status | Completed |
Enrollment | 36 |
Est. completion date | February 22, 2013 |
Est. primary completion date | February 22, 2013 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - patients presenting with RA according to ACR87 and ACR/EULAR 2010 criteria - patients presenting with RA anti-citrullinated peptide antibodies positive - patients presenting with active RA, characterized by at least one synovitis - patients presenting with an arthritis requiring arthrocentesis and synovial fluid collection for diagnostic or therapeutic purpose - patients giving agreement to participate to the study and to sign informed consent. Exclusion Criteria: - patients suffering from osteoarthritis - patients presenting with joint effusion justifying an arthrocentesis and synovial fluid collection for diagnostic of therapeutic purpose - patients giving agreement to participate to the study and to sign informed consent - Patients presenting with another arthropathy than anti-citrullinated peptide antibodies positive RA or osteoarthritis - Patients not requiring arthrocentesis for medical reasons - Patients refusing to sign informed consent - Patients presenting with understanding problems due to language or cognitive reasons. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Presence of bacterial DNA by 16s PCR | Detection by 16s PCR of DNA of bacterial origin in synovial fluid specimens | At the screening | |
Primary | Presence of a characteristic microbiota | Research of a characteristic microbiota of rheumatoid arthritis | At the screening |
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