Rheumatoid Arthritis Clinical Trial
Official title:
Foot Bone Mineral Density and Inflammation in Rheumatoid Arthritis
Significant increase in the levels of serum adiponectin, ADA, and hsCRP was reported in all
RA patients compared to controls.
Compared to patients with early RA, the increase in these markers significantly correlated
with disease activity (DAS-ESR), lower f-BMD, radiographic scoring, pain, FFI, and functional
limitations in patients with established RA.
Adiponectin showed a negative correlation with serum levels of both ADA and hsCRP. By using
ROC curve analysis, optimal cut-off values of adiponectin (28.8 µg/ml), ADA (27.3 IU/L), and
hsCRP (1.6 mg/L) could be used to estimate early RA in 45 % of the patients. Similarly, using
cut-off values of adiponectin (32.8 µg/ml), ADA (26.1 IU/L ml), and hsCRP (2.5 mg/L),
established RA could be predicted in 55 % of patients with 98-99% accuracy.
The present study attempts to evaluate the efficacy of adiponectin, ADA, and foot bone mineral density (fBMD) as predictors of the disease progression in patients with rheumatoid arthritis. A total of 80 RA patients and eighty age and sex-matched healthy controls were included in this study. ;
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