RheumatoId Arthritis Clinical Trial
Official title:
"ART REGISTRY : Rheumatoid Arthritis and Anti-TNF"
Rheumatoid arthritis (RA) is a complex and multifactorial autoimmune disease. The biological
treatments that are currently available for the treatment of RA are the TNF-alpha
inhibitors. Tumor necrosis factor (TNF) is a dominant cytokine in the inflammatory process
of rheumatoid arthritis. The anti-TNFs were the first to enter the market, and they
revolutionised the prognoses of patients with RA. They remain the most common first-line
biotherapy and are the most used at this time.
The French Society of Rheumatologists intends to coordinate a prospective national registry
study for this follow-up.
This registry will include 1500 RA patients from the start of treatment with anti-TNF-α and
then followed for 5 years, regardless of the therapeutic modifications occurring thereafter.
This registry is an observational, multicentre, longitudinal, prospective registry study The
objectives of this registry is to contribute 1) to evaluate the therapeutic management of
patients; and 2) to improve this therapeutic management.
Design: Observational, multicentre, longitudinal, prospective registry Primary objective: To
evaluate the real life efficacy and safety of anti-TNF inhibitors in patients with RA using
a prospective national registry.
Target population: Patients initiating anti-TNF therapy for RA (including infliximab,
adalimumab, etanercept, certolizumab and golimumab, and their respective biosimilar
according to their arrival on the market) Number of patients and centres : More than 80
centers in France (hospital-based, public and private practice) Recruitment period: 3 years
Follow-up: 5 years
;
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