Rheumatoid Arthritis Clinical Trial
Official title:
Phase 3 Study of ASP015K - A Randomized, Double-blind, Placebo-controlled Confirmatory Study of the Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis Who Had an Inadequate Response to DMARDs
The objective of this study was to verify the superiority of ASP015K alone or in combination with disease-modifying antirheumatic drugs (DMARDs) over placebo in terms of efficacy in participants with rheumatoid arthritis (RA) who had an inadequate response to DMARDs
This was a multi-center, randomized, placebo-controlled, double-blind, parallel-group,
confirmatory study to evaluate the efficacy and safety of ASP015K alone or in combination
with DMARDs in participants with RA who had an inadequate response to DMARDs.
Etanercept was also administered as the reference drug in an open-label manner. The study
drug was orally administered once daily (QD) after breakfast for 52 weeks. Etanercept was
administered subcutaneously QD for 52 weeks. At Week 12, participants in the placebo group
were switched to ASP015K.
The dose of ASP015K to be started at Week 12 for the placebo group was determined randomly at
baseline in advance and switched in a blinded manner.
Participants in ASP015K group or placebo groups who had completed the study were eligible for
participation in an open-label extension study (015K-CL-RAJ2).
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