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Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis — HLAPRPA  

Rheumatoid Arthritis Clinical Trial

Official title:
Study of HLA Polymorphisms in French West-Indian Patients With Rheumatoid Arthritis : A Case Control Study

Clinical Trial Summary

Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01111357
Study type Observational
Source Centre Hospitalier Universitaire de Fort-de-France
Contact
Status Completed
Phase N/A
Start date February 2010
Completion date August 2010
View Details
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