Rheumatoid Arthritis Clinical Trial
Official title:
Human TNFa-Induced Pre-B Cell Bone Marrow Emigrants
The purpose of the study is to determine the effects of TNF (tumor necrosis factor; a mediator of inflammation) on B cells in patients with rheumatoid arthritis. TNF and B cells are important in rheumatoid arthritis because they both appear to be involved in causing rheumatoid arthritis.
Primary Objective: The primary objective of the study is to identify early B cell bone
marrow emigrants in the peripheral blood of adults with rheumatoid arthritis (RA) receiving
etanercept.
Hypotheses: We believe that the peripheral blood of RA patients contain early B cell bone
marrow emigrants. We believe that these early B cell bone marrow emigrants are induced by
TNFα.
Primary Endpoint: The primary endpoint of the study is quantification of CD34+/CD19+ early B
cell bone marrow emigrants in the peripheral blood of subjects.
Study Design: Open-label, One Arm, Phase IV study of 12 RA patients with active disease
receiving etanercept.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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