Rheumatoid Arthritis Clinical Trial
— 3D sono in RAOfficial title:
Taichung Veterans General Hospital
Verified date | February 2015 |
Source | Taichung Veterans General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Institutional Review Board |
Study type | Observational |
The purpose of this study is to:
1. To investigate the wrist joint synovial blood flow intensity and model by quantitative
three-dimensional (3D) power Doppler ultrasonography (PDUS) in patients with rheumatoid
arthritis before and after initiation of a new medicine and compare these data with
routinely used clinical data and laboratory findings, such as pain score, erythrocyte
sedimentation rate (ESR) and C-reactive protein (CRP)
2. To investigate the intra-observer and inter-observer agreement of quantitative 3D PDUS
assessment of the vascularity in wrist joints and knee joints using automatic volume
scan.
Status | Completed |
Enrollment | 49 |
Est. completion date | March 2010 |
Est. primary completion date | March 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Patients who fulfill the 1987 ARA criteria for RA - Patients with at least one painful swollen wrist or knee joint observed by a rheumatologist - Patients who will receive a new medicine, including oral corticosteroid, intravenous methylprednisolone pulse therapy, intraarticular injection with steroid or methotrexate, DMARDs, or biologic agent Exclusion Criteria: - Patients with active infection - Patients with concurrent malignant disease - Patients with a history of traumatic, septic, or cystal arthritis, previous joint surgery, or arthroscopic synovectomy of any wrist or kneejoint within the past 12 months before the study - Patients who have severe wrist or knee joint deformity that makes the US assessment protocol unable to complete |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Taichung Veterans General Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Correlation between 2D- and 3D-PDUS quantification data and clinical data, including pain score, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) | cross-sectional | No |
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