Effect of Exercise on the Disease Activity of Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

— RA&Ex  

Official title:

Evaluation of the Effect of Exercise on Disease Activity and Immune Parameters in Persons With Rheumatoid Arthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00792675
• Other study ID #: 0267-02-FB
• Status: Completed
• Phase: N/A
• Start date: January 1, 2003
• Est. completion date: November 1, 2006

Study information

• Verified date: August 2023
• Source: University of Nebraska
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weightlifting.

Description:

The goal of this study was to evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis. It was hypothesized that persons would have less inflammation associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weighlifting. Immune parameters were measured to determine potential mechanisms responsible for changes in inflammation with exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 55
• Est. completion date: November 1, 2006
• Est. primary completion date: April 1, 2006
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• a diagnosis of RA according to the ACR 1989 Criteria at least 6 months prior to enrollment in the study, but not longer than 12 years
• age 19 to 65 years old
• stable regimen of medication for 2 months with less than 10 mg/day of oral corticosteroids
• currently exercise < 2x/week for less than 30 minutes at less than 60% of his/her age predicted maximum heart rate
• Subjects must pass the Physical Activity Readiness Scale Questionnaire (PAR-Q)

Exclusion Criteria:

• other serious health problems
• intra-articular injection within 6 weeks
• total joint replacement of the large joints
• use of beta-blockers
• inability to complete the submaximal exercise test

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Rheumatoid Arthritis

Intervention

Other:
• Aerobic and resistance exercise training
Exercise was performed 3 times per week. It consisted of 30 minutes of treadmill exercise at approximately 85% of heartrate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Locations

Country	Name	City	State
United States	Physical Activity Lab, University of Nebraska Omaha	Omaha	Nebraska

Sponsors (3)

Lead Sponsor	Collaborator
University of Nebraska	Arthritis Foundation, Nebraska Chapter Arthritis Foundation

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Swollen Joint Count		12 Weeks
Primary	Tender Joint Count		12 Weeks
Secondary	Pain (visual Analog Scale)		12 Weeks
Secondary	Modified-Health Assessment Questionnaire		12 Weeks
Secondary	Estimated Aerobic Capacity (VO2max)		12 weeks
Secondary	SF-36		12 Weeks
Secondary	Patient Global Assessment		12 Weeks
Secondary	Practitioner Global Assessment		12 Weeks
Secondary	Timed-Stands Test		12 Weeks
Secondary	50 Foot Walk Test		12 Weeks