Rheumatoid Arthritis Clinical Trial
Official title:
Comparison of the Effects of Simultaneous Administration of Vitamin E and Omega-3 Fatty Acids in Patients With Rheumatoid Arthritis
The purpose of this study is to determine whether simultaneous supplementation with omega-3 fatty acids and vitamin E is effective in the treatment of patients with rheumatoid arthritis.
The purpose of this study is to determine whether simultaneous supplementation with omega-3
fatty acids and vitamin E is effective in the treatment of patients with rheumatoid
arthritis.
Most of studies on omega-3 fatty acids (omega-3) supplementation in patients with rheumatoid
arthritis (RA) have clearly shown potentially beneficial changes in cytokine and eicosanoid
metabolism. The overall clinical improvement, however, has been only moderate. One
explanation is that an increased intake of omega-3 leads to a reduction in the availability
of antioxidants and an increased generation of lipid peroxides. The majority of the
anti-inflammatory drugs routinely used nowadays are COX (cyclo-oxygenase) inhibitors.
Mechanism of COX II inhibitors is similar of omega-3. So, it is difficult to differentiate
omega-3 net effects in some situations. Existing clinical trials on omega-3 and vitamin E
(Vit E) are sometimes questioned due to using omega-6 fatty acids as placebo and neglecting
omega-6 fatty acid intake in the diet. A comprehensive randomized controlled double-blind
trial would have omega-6 fatty acids served as placebo in patients who are well matched in
terms of therapies and drugs.
Comparison(s): Comparison of groups supplemented with omega-3, omega-3 with Vit E, and
placebo (Medium chain triglycerides: MCT).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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