Rheumatoid Arthritis Clinical Trial
The study aimed to investigate effects of radon (plus CO2) baths on RA in contrast to
artificial CO2 baths in RA rehabilitation.
134 patients of an in-patient rehabilitative programme were randomly assigned to the groups.
Outcomes were limitations in occupational context/ daily living (main outcome), pain,
medication, etc. measured before start, after end of treatment, and up to a year thereafter.
Superiority of radon treatment was found regarding reduced limitations in daily living until
12 months after end of treatment. Steroid consumption and NSAIDs were significantly reduced.
Objective: To replicate former observed beneficial effects of Radon (plus CO2) baths on RA
in contrast to artificial CO2 baths and to investigate its long-term effectiveness and
impact on drug consumption.
Methods: Randomised double-blinded trial with 2 randomised balanced groups enrolling 134
patients of an in-patient rehabilitative programme (a 3rd non-randomised group of 73
consecutive patients is not reported here). Outcomes were limitations in occupational
context/ daily living, pain, functional capacity, morning stiffness and medication measured
before start, after end of treatment, and quarterly in the year thereafter.
Repeated-measures analysis of covariance (RM-ANCOVA) of intent-to treat population was
performed to investigate treatment effects. Hierarchically ordered hypotheses ensured
adherence of the nominal significance level and allowed examining of long-term effects.
Starting with all measures until 6 months’ follow-up, significant main effects for group
allocation (GME) or significant group x course-interactions (GxC) were regarded essential to
add the next follow-up for analysis.
Results: Radon treatment resulted in significantly lower limitations of daily living over at
least 9 months whereas reference patients returned to baseline level after 6 months already
(RM-ANCOVA until 6 months: pGME=.15, pGxC=.016/ 9 months: pGME=.11, pGxC=.025/ 12 months:
pGME=.17, pGxC=.033). Furthermore, consumption of steroids and NSAID was remarkably reduced
in the Radon group (RM-ANCOVA until 12 months: for steroids pGME=.064, interaction
pGxC=.025, maximum difference after 12 months; for NSAID pGME=.035, interaction pGxC=.008,
maximum difference after 9 months).
Conclusion: Results suggest beneficial long-term effects of Radon baths as adjunct to a
multimodal rehabilitative treatment of RA.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04226131 -
MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics
|
N/A | |
Completed |
NCT04171414 -
A Study to Evaluate Usability of Subcutaneous Auto-injector of CT-P17 in Patients With Active Rheumatoid Arthritis
|
Phase 3 | |
Completed |
NCT02833350 -
Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)
|
Phase 2 | |
Completed |
NCT04255134 -
Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)
|
Phase 4 | |
Recruiting |
NCT05615246 -
Exactech Humeral Reconstruction Prosthesis of Shoulder Arthroplasty PMCF (HRP)
|
||
Completed |
NCT03248518 -
Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases
|
N/A | |
Completed |
NCT03514355 -
MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms
|
N/A | |
Recruiting |
NCT06005220 -
SBD121, a Synbiotic Medical Food for RA Management
|
N/A | |
Recruiting |
NCT05451615 -
Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis
|
Phase 3 | |
Completed |
NCT05054920 -
Eccentric Versus Concentric Exercises for Rotator Cuff Tendinopathy in Patients With Rheumatoid Arthritis
|
N/A | |
Completed |
NCT02037737 -
Impact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life Setting
|
N/A | |
Recruiting |
NCT04079374 -
Comparative Efficacy, Safety and Immunogenicity Study of Etanercept and Enbrel
|
Phase 3 | |
Completed |
NCT02504268 -
Effects of Abatacept in Patients With Early Rheumatoid Arthritis
|
Phase 3 | |
Recruiting |
NCT05496855 -
Remote Care in People With Rheumatoid Arthritis
|
N/A | |
Completed |
NCT05051943 -
A Study of the Real-world Use of an Adalimumab Biosimilar and Evaluation of Nutritional Status on the Therapeutic Response
|
||
Recruiting |
NCT06031415 -
Study of GS-0272 in Participants With Rheumatoid Arthritis
|
Phase 1 | |
Recruiting |
NCT06103773 -
A Study of Single and Multiple Oral Doses of TollB-001
|
Phase 1 | |
Completed |
NCT05999266 -
The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
|
||
Recruiting |
NCT05302934 -
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
|
||
Recruiting |
NCT04169100 -
Novel Form of Acquired Long QT Syndrome
|
Phase 4 |