Rheumatoid Arthritis Clinical Trial
Official title:
An Enabling Study to Investigate the Correlation of Biomarkers of the Activity of Inducible Nitric Oxide Synthase (iNOS) With Disease Activity and Treatment Response in Patients With Rheumatoid Arthritis(RA)
NCT number | NCT00242853 |
Other study ID # | RA4102651 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | October 19, 2005 |
Last updated | October 9, 2008 |
Start date | October 2004 |
This study is being conducted to validate various biomarkers in patients with RA with varying levels of disease severity. Subjects with a diagnosis of rheumatoid arthritis (RA) will be included as controls. The sudy will measure the baseline levels and the intra- and inter-subject variability of exhaled nitric oxide (NO) in patients with inactive/mild and moderate/severe RA on stable therapy or during a course glucocorticoids. In addition exhaled NO levels will be correlated with intra-articular inflammation (power Doppler ultrasonography) as well as markers of systemic inflammation (CRP, ESR).
Status | Completed |
Enrollment | 48 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion criteria: - Diagnosis of rheumatoid or osteo-arthritis. - Weight greater than 45kg (females) or 50kg (males) but not overweight. - Non-smokers. - Taking stable anti-inflammatory medication for Rheumatoid Arthritis (RA) or Osteoarthritis (OA) for at least 8 weeks. Exclusion criteria: - Taking regular doses of glucocorticoid medication (greater than 5mg/day). - Currently taking biological treatment for RA. - Recent participation in another clinical trial. |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United Kingdom | GSK Investigational Site | London |
Lead Sponsor | Collaborator |
---|---|
GlaxoSmithKline |
United Kingdom,
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