Rheumatoid Arthritis Clinical Trial
Official title:
H215O Positron Emission Tomography (PET) in the Assessment of Synovial Blood Flow in Rheumatoid Arthritis Patients
This study will test whether positron emission tomography (PET) imaging can be used to
measure blood flow to joints in patients with rheumatoid arthritis (RA). It will also
compare blood flow measurements using PET with measurements obtained with magnetic resonance
imaging (MRI) to determine how useful MRI is in measuring blood flow to joints.
Much of the joint damage in RA is caused by the synovium-the lining of the joint. In RA, the
synovium increases in size and destroys bone and cartilage. The synovium maintains its
growth by forming many new small blood vessels to nourish it. New drug treatments are being
developed to stop the growth of these new blood vessels. The effect of these treatments on
the synovium is usually measured by performing a biopsy-removing a small piece of synovium
for examination under a microscope. The biopsy requires inserting a needle into the joint to
withdraw the synovial tissue. This study will see if changes in blood flow can be assessed
accurately using noninvasive imaging procedures, such as PET scanning, instead of a biopsy.
Patients 18 years of age and older with rheumatoid arthritis who have at least one tender
and swollen knee due to synovitis may be eligible for this study. Candidates will be
screened with a medical history and physical examination.
Participants will have a mold made of the knee to be studied and will have routine blood
tests. Women who are able to become pregnant will have a pregnancy test. All participants
will then undergo PET and MRI scanning as described below:
PET - A needle is used to insert a catheter (small plastic tube) into an arm vein for
injection of the radioactive substance H215O. The patient lies in a doughnut-shaped machine
(the PET scanner) and a quick scan is done to measure body thickness. Then, a separate scan
is taken following each of six or fewer injections of H215O. Each scan lasts about 13
minutes.
MRI - The patient lies on a stretcher that is moved into a cylinder containing a magnetic
field (the MRI scanner). A special coil is placed over the knee to improve the quality of
the images. Earplugs are worn to muffle the loud thumping sound produced by electrical
switching of the magnetic fields during the imaging. A contrast agent called gadolinium is
injected through a catheter into a vein to improve the quality of the images. An intercom
system permits the patient to communicate with the technician at all times during the
procedure.
Status | Completed |
Enrollment | 10 |
Est. completion date | March 2003 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA: 18 years of age or greater. Must meet the American College of Rheumatology's diagnostic criteria for RA(21). Must have or have had synovitis in at least one knee characterized by tenderness, swelling, or effusion within 30 days prior to screening. Women must test negative on a pregnancy test unless they are post-menopausal or surgically sterile. EXCLUSION CRITERIA: Patients with concurrent known bacterial, septic, or crystal-induced arthritis, or with other rheumatic diseases that may confound the analysis including but not limited to Lyme disease, psoriatic arthritis, spondylarthropathy, systemic lupus erythematosus, or reactive arthritis. Patients who would be beyond the guidelines for radiation exposure from research studies within the past year. Patients who exceed the size or weight limitations of the PET or MRI scanner. Patients who suffer from claustrophobia or who have any of the following: cardiac pacemakers, auto defibrillators, neural stimulators, aneurysm clips, metallic prostheses, cochlear (ear) implants, any implanted devices (pumps, infusion devices, etc), metal fragments in the eye, or shrapnel injuries. Any musculoskeletal, neurological, or vascular condition that may alter the normal function and structure of knee joint of interest or will interfere the patient's ability to undergo study-related intervention and imaging. Any clinically significant medical condition that, in the opinion of the investigator, would pose added risk for study participants. History of allergic or non-allergic serious reaction to gadolinium, or H2 15O PET. Pregnant women or nursing mothers. |
Endpoint Classification: Safety Study, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
United States,
Choudhury L, Elliott P, Rimoldi O, Ryan M, Lammertsma AA, Boyd H, McKenna WJ, Camici PG. Transmural myocardial blood flow distribution in hypertrophic cardiomyopathy and effect of treatment. Basic Res Cardiol. 1999 Feb;94(1):49-59. — View Citation
Eliceiri BP, Cheresh DA. The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest. 1999 May;103(9):1227-30. Review. — View Citation
Walsh DA. Angiogenesis and arthritis. Rheumatology (Oxford). 1999 Feb;38(2):103-12. Review. — View Citation
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