Retinoblastoma Clinical Trial
Official title:
Prospective Analysis of Serious Cardio-respiratory Events During Ophthalmic Artery Chemotherapy for Retinoblastoma Under a Deep and Standardized Anesthesia
Background: Serious adverse cardio-respiratory events (SCRE) occur during super selective
ophthalmic artery chemotherapy for retinoblastoma in children. SCRE mechanism remains
unclear but may be attributed to an autonomic nervous reflex induced by catheterization of
the ophthalmic artery. The investigators hypothesize that inadequacy between depth of
anesthesia and catheter stimulation might be a support cause of these SCRE.
Methods: Children requiring super selective ophthalmic artery chemotherapy for
retinoblastoma are prospectively included in this observational study. Endovascular
procedures are performed under standardized and deep general anesthesia with sevoflurane,
sufentanil and rocuronium. SCRE are strictly pre-defined and included arterial hypotension,
bradycardia and bronchospasm. SCRE are recorded and the factors influencing their occurrence
are investigated.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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