Intravitreal Injections of Melphalan for Retinoblastoma

Status Terminated

Clinical Trial Summary

Retinoblastoma treatment has become more and more focused in the last years. New treatments developed by Dr. Kaneko from Japan in 1995 are now being tested in clinical trials.

Intra-arterial chemotherapy with Melphalan has shown success in some patients but with limited response when there is marked vitreal seeding. For these cases Intravitreal injections of Melphalan have been successful in Japan.

In this study the same chemotherapy (melphalan) will be administered intravitreally (directly through the eye wall) and the response (short and long term) will be monitored.

Clinical Trial Description

Intravitreal injections of Melphalan will be given to cases unresponsive to chemotherapy or with vitreal seeding of the disease. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Retinoblastoma

Clinical Trial Details

NCT number	NCT01558960
Study type	Interventional
Source	Hadassah Medical Organization
Contact
Status	Terminated
Phase	N/A
Start date	March 2012
Completion date	August 2015

View Details

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